Modulatory effects of fMRI acquisition time of day, week and year on adolescent functional connectomes across spatial scales: Implications for inference
Modulatory effects of fMRI acquisition time of day, week and year on adolescent functional connectomes across spatial scales: Implications for inference
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DOI：
10.1016/j.neuroimage.2023.120459
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发表时间：
2023-11-18
期刊：
影响因子：
5.7
通讯作者：
Stamoulis，Catherine
中科院分区：
文献类型：
--
作者：
Hu，Linfeng;Katz，Eliot S.;Stamoulis，Catherine
代谢、激素、自主神经和生理节律可能对脑血流动力学和用功能磁共振成像（静息状态连接体）测量的内在脑同步性有显著影响。他们的特征时间尺度（每小时，昼夜节律，季节性）的影响，因此扫描时序效应，在本质上异质性发展中的连接体的大脑拓扑结构仍然难以捉摸。在青少年脑认知发育研究中，在4102名具有静息状态fMRI的早期青少年（中位年龄= 120.0个月; 53.1%女性）中，本研究调查了扫描时间，每周时间（上学日与周末）和一年中的时间（学年与暑假）之间的关联以及多个空间尺度下静息状态连接体的拓扑特性。平均而言，参与者在下午2点左右进行扫描，主要是在上学期间（60.9%）和学年期间（74.6%）。扫描时间的一天是负相关的多个全脑，网络特定的和区域的拓扑特性（与模块化的正相关性除外），主要是视觉，背侧注意，显着性，额顶叶控制网络，和基底神经节。在周末（与上学日相比）进行扫描与海马和颞顶网络的拓扑差异有关。被扫描在暑假期间（与学年）始终与双边视觉的多个拓扑特性，并在较小程度上somatomotor，背侧注意和颞顶网络正相关。时间参数的相互作用表明，在周末和暑假期间被扫描增强了在早上被扫描的积极影响。日时效应总体上较小，但在空间上广泛，周时效应和年时效应从小到大不等（Cohen'sf≤ 0.1，Cohen'd<0.82，p < 0.05）。总之，这些参数也正相关的时间功能磁共振成像信号的变异性，但仅在左半球。最后，使用ABCD神经认知成套测验评估了扫描时间参数对连接体属性和认知任务性能之间关系的混杂效应。虽然大多数的关系不受扫描时间参数，他们的组合包含消除视觉和躯体运动网络的属性和性能之间的关联矩阵推理和模式比较处理速度任务。因此，一天、一周和一年中的扫描时间可能会影响青少年大脑功能回路的测量，并且应该在关于其与认知表现的关联的研究中加以考虑，以减少不正确推断的概率。
Metabolic, hormonal, autonomic and physiological rhythms may have a significant impact on cerebral hemodynamics and intrinsic brain synchronization measured with fMRI (the resting-state connectome). The impact of their characteristic time scales (hourly, circadian, seasonal), and consequently scan timing effects, on brain topology in inherently heterogeneous developing connectomes remains elusive. In a cohort of 4102 early adolescents with resting-state fMRI (median age = 120.0 months; 53.1 % females) from the Adolescent Brain Cognitive Development Study, this study investigated associations between scan time-of-day, time-of-week (school day vs weekend) and time-of-year (school year vs summer vacation) and topological properties of resting-state connectomes at multiple spatial scales. On average, participants were scanned around 2 pm, primarily during school days (60.9 %), and during the school year (74.6 %). Scan time-of-day was negatively correlated with multiple whole-brain, network-specific and regional topological properties (with the exception of a positive correlation with modularity), primarily of visual, dorsal attention, salience, frontoparietal control networks, and the basal ganglia. Being scanned during the weekend (vs a school day) was correlated with topological differences in the hippocampus and temporoparietal networks. Being scanned during the summer vacation (vs the school year) was consistently positively associated with multiple topological properties of bilateral visual, and to a lesser extent somatomotor, dorsal attention and temporoparietal networks. Time parameter interactions suggested that being scanned during the weekend and summer vacation enhanced the positive effects of being scanned in the morning. Time-of-day effects were overall small but spatially extensive, and time-of-week and time-of-year effects varied from small to large (Cohen'sf≤ 0.1, Cohen's d<0.82,p< 0.05). Together, these parameters were also positively correlated with temporal fMRI signal variability but only in the left hemisphere. Finally, confounding effects of scan time parameters on relationships between connectome properties and cognitive task performance were assessed using the ABCD neurocognitive battery. Although most relationships were unaffected by scan time parameters, their combined inclusion eliminated associations between properties of visual and somatomotor networks and performance in the Matrix Reasoning and Pattern Comparison Processing Speed tasks. Thus, scan time of day, week and year may impact measurements of adolescent brain's functional circuits, and should be accounted for in studies on their associations with cognitive performance, in order to reduce the probability of incorrect inference.