Prevalence and heritability of the metabolic syndrome and its individual components in a Dutch isolate: the Erasmus Rucphen Family study
Prevalence and heritability of the metabolic syndrome and its individual components in a Dutch isolate: the Erasmus Rucphen Family study
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DOI：
10.1136/jmg.2008.058388
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发表时间：
2008-09-01
影响因子：
4
通讯作者：
van Duijn, C. M.
中科院分区：
文献类型：
--
作者：
Henneman, P.;Aulchenko, Y. S.;van Duijn, C. M.
背景资料：代谢综合征（MetS）是由异常的组合定义的，这些异常都是2型糖尿病和/或心血管疾病发展的个体风险因素。MetS的病因学包括环境和遗传成分。我们研究了MetS和它的个别组成部分Dutch genetic isolation.Methods的患病率和遗传性：伊拉斯谟鲁克芬家庭研究（ERF）由大约3000个家系记录的个人从荷兰的遗传隔离。可获得腰围（WC）、血压（BP）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）和空腹血糖值（FPG）的数据。根据国际糖尿病联合会（IDF）（2003）和国家胆固醇教育计划成人组III（NCEP ATP III）标准定义MetS。方差分量分析应用于大家庭的数据，以测试遗传力的证据。结果：在ERF队列的MetS的患病率范围从23 - 37%，这取决于MetS的定义和性别考虑。低HDL-C和高WC是代谢综合征的主要因素。根据IDF和NCEP ATPIII标准，MetS的遗传率校正为同胞效应为10.6%（p = 0.01）和13.2%（p = 0.07）。此外，还对MetS各组分的遗传力进行了分析，结果表明，MetS各组分的遗传力在21.9 - 42.9%之间。HDL-C（42.9%，p，0.0001）和WC（37.8%，p，0.0001）的遗传率最高。此外，WC、收缩压、HDL-C和TG在性别间均表现出低至中度的遗传相关（RhoG），而FPG和舒张压在性别间表现出绝对的遗传相关。结论：ERF人群中MetS患病率较高，但MetS的遗传度为中度。代谢综合征各组分的高遗传力表明，对代谢综合征的遗传解剖应从其各组分着手。
Background: Metabolic syndrome (MetS) is defined by a combination of abnormalities that are all individual risk factors for the development of type 2 diabetes and/ or cardiovascular disease. The aetiology of MetS includes both an environmental and genetic component. We studied the prevalence and heritability of MetS and its individual components Dutch genetic isolate.Methods: The Erasmus Rucphen Family study (ERF) consists of some 3000 genealogically documented individuals from a Dutch genetic isolate. Data on waist circumference (WC), blood pressure (BP), high density lipoprotein cholesterol (HDL-C), triglycerides (TG) and fasting plasma glucose values (FPG) are available. MetS was defined according to the International Diabetes Federation (IDF) (2003) and National Cholesterol Education program Adult Panel III (NCEP ATPIII) criteria. Variance component analysis was applied to extended family data to test for evidence of heritability.Results: The prevalence of MetS in the ERF cohort ranged from 23 -37% depending on MetS definition and gender considered. Low HDL-C and high WC are the main contributors to MetS. The heritability of MetS corrected for sibship effect was 10.6% (p= 0.01) according to IDF and 13.2% (p= 0.07) according to NCEP ATPIII criteria. In addition, the heritability of individual components of MetS were analysed and found to range from 21.9 -42.9%. The highest heritability was found for HDL-C (42.9%, p, 0.0001) and WC (37.8%, p, 0.0001). In addition, WC, systolic BP, HDL-C and TG showed low to moderate genetic correlation (RhoG) between genders, whereas FPG and diastolic BP showed absolute genetic correlation between genders.Conclusion: Although the prevalence of MetS was high, the heritability of MetS in the ERF population was found to be moderate. The high heritability of the individual components of MetS indicates that the genetic dissection of MetS should be approached from its individual components.