Fine control of the release and encapsulation of Fe ions in dendrimers through ferritin-like redox switching.
Fine control of the release and encapsulation of Fe ions in dendrimers through ferritin-like redox switching.
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DOI：
10.1021/ja037480p
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发表时间：
2004-01
影响因子：
15
通讯作者：
Reina Nakajima;Masanori Tsuruta;M. Higuchi;Kimihisa Yamamoto
中科院分区：
文献类型：
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作者：
Reina Nakajima;Masanori Tsuruta;M. Higuchi;Kimihisa Yamamoto
许多含有金属离子或簇的树枝状聚合物作为催化和药物输送材料受到了广泛关注。我们通过径向逐步络合扩大了与 DPA 络合的金属离子种类，创造出新型有机-无机杂化材料。使用 Fe3+ 作为最常见和最重要的铁离子之一。据证实，铁离子 FeCl3 以逐步径向方式与球形苯基偶氮甲碱树枝状聚合物 (DPA) 的亚胺基团配位，这使得控制掺入树枝状聚合物中的 Fe3+ 离子的数量和位置成为可能。铁具有非常有趣的特性，例如磁性、氧化还原化学和催化作用，也是我们身体的必需元素之一。在这里，我们展示了首次成功地尝试控制由 Fe2+/Fe3+ 对的氧化还原反应驱动的树枝状大分子中铁离子释放/封装的仿生转换，这可能会用作药物输送系统。
Numerous dendrimers incorporating metal ions or clusters have received much attention as catalytic and drug delivery materials. We expanded the variety of metal ions that complex with DPA through a radial stepwise complexation to create novel organic-inorganic hybrid materials. As one of the most common and significant iron ions, Fe3+ was used. It was confirmed that iron ions, FeCl3, are coordinated to the imine groups of a spherical phenylazomethine dendrimer (DPA) in a stepwise radial fashion, which should make it possible to control the number and location of the Fe3+ ions incorporated into the dendrimers. Iron possesses very interesting properties such as magnetism, redox chemistry, and catalysis and is also one of the essential elements of our body. Here, we show the first successful attempt to control the biomimetic switching of iron ions' release/encapsulation in the dendrimer driven by their redox response of the Fe2+/Fe3+ couple, which might find uses as a drug delivery system.