Project Baby Bear: Rapid precision care incorporating rWGS in 5 California children's hospitals demonstrates improved clinical outcomes and reduced costs of care
Project Baby Bear: Rapid precision care incorporating rWGS in 5 California children's hospitals demonstrates improved clinical outcomes and reduced costs of care
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DOI：
10.1016/j.ajhg.2021.05.008
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发表时间：
2021-07-01
影响因子：
9.8
通讯作者：
Farnaes, Lauge
中科院分区：
文献类型：
--
作者：
Dimmock, David;Caylor, Sara;Farnaes, Lauge
遗传疾病是新生儿和儿科重症监护病房(ICU)死亡率的主要贡献者。基于快速全基因组测序(RWGS)的快速精确医学(RPM)是一种已证明改善临床结果和降低护理成本的干预措施。然而，广泛临床部署的可行性尚未确定。这项研究的目的是实施基于rWGS的RPM，并评估该实施作为加州医疗补助(Medi-Cal)计划的一线诊断测试的临床和经济影响。Baby Bear项目是一个由付款人资助的、预期的、真实世界的质量改进项目，在五家三级护理儿童医院的地区ICU中进行。参与仅限于2018年11月至2020年5月收治的危重Medi-Cal受益人，
Genetic disorders are a leading contributor to mortality in neonatal and pediatric intensive care units (ICUs). Rapid whole-genome sequencing (rWGS)-based rapid precision medicine (RPM) is an intervention that has demonstrated improved clinical outcomes and reduced costs of care. However, the feasibility of broad clinical deployment has not been established. The objective of this study was to implement RPM based on rWGS and evaluate the clinical and economic impact of this implementation as a first line diagnostic test in the California Medicaid (Medi-Cal) program. Project Baby Bear was a payor funded, prospective, real-world quality improvement project in the regional ICUs of five tertiary care children's hospitals. Participation was limited to acutely ill Medi-Cal beneficiaries who were admitted November 2018 to May 2020, were