MHC class II inhibits the generation of IL‐17A <sup>+</sup> Vγ6 γδ T cells in the thymus at perinatal stage
MHC class II inhibits the generation of IL‐17A <sup>+</sup> Vγ6 γδ T cells in the thymus at perinatal stage
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MHC II 类抑制围产期胸腺中 IL-17A <sup>+</sup> Vγ6 γδ T 细胞的生成
DOI：
10.1002/eji.202149542
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发表时间：
2022
影响因子：
5.4
通讯作者：
Yoshikai Yasunobu
中科院分区：
文献类型：
--
作者：
Hatano Shinya;Mine Keiichiro;Noguchi Naoto;Matsumoto Mitsuru;Baba Yoshihiro;Yoshikai Yasunobu
摘要与WT小鼠相比，MHC II类KO小鼠CD3 SP+SP TCR SP-SP T细胞发育受损，但缺乏MHC II类时T细胞数量增加。MHC II类抑制围产期胸腺IL-17A+V6 T细胞的生成为了确定MHC II类对T细胞发育的影响，我们首先研究了新生儿胸腺中T细胞的V谱系，此时V6 SP+SP T细胞处于高峰水平[6]。关键词：T细胞；V 6；MHC II类；IL-17A；mTEC EN T细胞V 6 MHC II IL-17A mTEC 1366 1368 3 08/08/22 20220801 NES 220801 V 6 SP+SP T细胞在围产期在胸腺发育，是T细胞中唯一的IL-17A产生者。[摘自文章]《欧洲免疫学杂志》版权归威利-布莱克韦尔所有，未经版权所有者明确的书面许可，不得将其内容复制或通过电子邮件发送到多个站点或发布到列表服务器。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对复制品的准确性不作任何保证。用户应参考该材料的原始出版版本，以获取完整摘要。版权适用于所有摘要。
Abstract CD3 SP+ sp TCR SP-sp T cell development was impaired in MHC class II KO mice, but T cells were increased in the absence of MHC class II compared with WT mice (Fig. MHC class II inhibits the generation of IL-17A+V 6 T cells in the thymus at perinatal stage To determine the effects of MHC class II on T cell development, we first investigated the V repertoire of T cells in the newborn thymus, at which time V 6 SP+ sp T cells are present at a peak level [6]. Keywords: T cells; V 6; MHC class II; IL-17A; mTEC EN T cells V 6 MHC class II IL-17A mTEC 1366 1368 3 08/08/22 20220801 NES 220801 V 6 SP+ sp T cells develop in the thymus at the perinatal stage and are exclusive IL-17A producers among T cells.[Extracted from the article]Copyright of European Journal of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.