Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks.
Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks.
复制标题
蜜蜂行为的个体差异是由大脑基因调控网络的可塑性实现的。
DOI：
10.7554/elife.62850
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发表时间：
2020-12-22
期刊：
影响因子：
7.7
通讯作者：
Robinson GE
中科院分区：
文献类型：
--
作者：
Jones BM;Rao VD;Gernat T;Jagla T;Cash-Ahmed AC;Rubin BE;Comi TJ;Bhogale S;Husain SS;Blatti C;Middendorf M;Sinha S;Chandrasekaran S;Robinson GE
了解表型变异的调控结构是生物学的一个基本目标，但基因调控网络（GRN）活性和个体行为差异之间的联系知之甚少。我们的特点是行为可塑性的分子基础，在无蜂王蜜蜂（蜜蜂）殖民地，其中个人从事生殖和非生殖行为。使用高通量行为跟踪，我们发现这些殖民地包含一个连续的表型，一些个体专门用于产卵或觅食，而“通才”则同时执行这两项任务。大脑基因表达和染色质可及性与行为变异相关，通才在行为和分子特征方面处于中间地位。为个体构建的脑GRNs模型显示，转录因子（TF）活性对行为具有高度预测性，并且行为相关的调节区域具有更多的TF基序。这些结果为大脑GRN可塑性在行为调节中所起的重要作用提供了新的见解，并对社会进化产生了影响。
Understanding the regulatory architecture of phenotypic variation is a fundamental goal in biology, but connections between gene regulatory network (GRN) activity and individual differences in behavior are poorly understood. We characterized the molecular basis of behavioral plasticity in queenless honey bee (Apis mellifera) colonies, where individuals engage in both reproductive and non-reproductive behaviors. Using high-throughput behavioral tracking, we discovered these colonies contain a continuum of phenotypes, with some individuals specialized for either egg-laying or foraging and ‘generalists’ that perform both. Brain gene expression and chromatin accessibility profiles were correlated with behavioral variation, with generalists intermediate in behavior and molecular profiles. Models of brain GRNs constructed for individuals revealed that transcription factor (TF) activity was highly predictive of behavior, and behavior-associated regulatory regions had more TF motifs. These results provide new insights into the important role played by brain GRN plasticity in the regulation of behavior, with implications for social evolution.