Tumor Immune Microenvironments (TIMEs): Responsive Nanoplatforms for Antitumor Immunotherapy.
Tumor Immune Microenvironments (TIMEs): Responsive Nanoplatforms for Antitumor Immunotherapy.
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肿瘤免疫微环境（TIMEs）：抗肿瘤免疫治疗的响应性纳米平台
DOI：
10.3389/fchem.2020.00804
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发表时间：
2020
影响因子：
5.5
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Sui X;Jin T;Liu T;Wu S;Wu Y;Tang Z;Ren Y;Ni D;Yao Z;Zhang H
由于与传统方法相比，肿瘤免疫治疗具有许多优点，如高效和防止转移，因此对癌症免疫治疗的兴趣迅速上升。研究主要集中在调节机体抗肿瘤免疫反应机制的两个主要策略上：旨在放大免疫激活的“增强免疫疗法”和纠正肿瘤免疫微环境(TIMES)中缺陷免疫机制的“归一化免疫疗法”，使其回到正常的免疫轨迹。然而，由于时代的复杂性和异质性，以及对免疫治疗过程缺乏可视化研究，肿瘤免疫治疗还没有在临床上得到广泛的应用。最近，通过对纳米材料的设计和修饰，人们开发了智能的时间响应型纳米平台，在免疫治疗的许多方面都取得了令人鼓舞的成果。在这篇简短的综述中，强调了基于纳米平台的免疫调节所设计的纳米材料的地位，特别是关于上述方法。据设想，未来的前景将集中在多种免疫疗法的组合上，以更有效地抑制和消除癌症。
Interest in cancer immunotherapy has rapidly risen since it offers many advantages over traditional approaches, such as high efficiency and prevention of metastasis. Efforts have primarily focused on two major strategies for regulating the body's antitumor immune response mechanisms: “enhanced immunotherapy” that aims to amplify the immune activation, and “normalized immunotherapy” that corrects the defective immune mechanism in the tumor immune microenvironments (TIMEs), which returns to the normal immune trajectory. However, due to the complexity and heterogeneity of the TIMEs, and lack of visualization research on the immunotherapy process, cancer immunotherapy has not been widely used in clinical setting. Recently, through the design and modification of nanomaterials, intelligent TIME-responsive nanoplatforms were developed from which encouraging results in many aspects of immunotherapy have been achieved. In this mini review, the status of designed nanomaterials for nanoplatform-based immune regulation of TIMEs has been emphasized, particularly with respect to the aforementioned approaches. It is envisaged that future prospects will focus on a combination of multiple immunotherapies for more efficient cancer inhibition and elimination.