Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening
Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening
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DOI：
10.1021/acsami.1c06774
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发表时间：
2021-07-22
影响因子：
9.5
通讯作者：
Tian, Weidong
中科院分区：
文献类型：
--
作者：
Hu, Xingyu;Xie, Li;Tian, Weidong
对迷人微笑的需求日益增长，导致牙齿漂白程序的普及。目前的牙齿漂白产品含有高浓度的过氧化氢（HP，30-40%）是有效的，但由于增加了牙釉质破坏，牙齿敏感和牙龈刺激的风险而有害。在此，我们报道了一种低浓度HP的低破坏性和有效的牙齿美白策略，这是通过显着增强的缺氧TiO 2（TiO 2-x）的类Fenton催化活性来实现的。采用改进的NaBH 4固相化学还原法合成了TiO 2-x纳米粒子。通过控制氧空位浓度优化了TiO 2-x的类Fenton活性，并通过近红外（NIR）诱导的TiO 2-x的光热效应进一步促进了其类Fenton活性。在所获得的样品中，由于亚甲基蓝（MB）吸附能力和类Fenton活性最高，因此选择命名为BT45的TiO 2-x样品。在808 nm近红外辐射下验证了BT45的光热性质，并研究了其对类Fenton活性的增强作用。在各种变色牙齿（被橙子II、茶或罗丹明B染色）上，BT 45/HP + NIR组在牙齿美白方面的表现显著优于HP + NIR组。令人兴奋的是，与Opalescence Boost，牙齿漂白产品含有40%的HP，通过基于这个新的系统含有12%的HP自制的漂白凝胶获得相同的牙齿美白性能。此外，可忽略的牙釉质破坏，安全的温度范围，和良好的细胞相容性的TiO 2-x纳米粒子也证明了这种牙齿漂白策略的安全性。这项工作表明，光热增强的Fenton类性能的TiO 2-x为基础的系统是非常有前途的牙齿漂白应用，也可以扩展到其他生物医学应用。
The growing demand for charming smiles has led to the popularization of tooth bleaching procedures. Current tooth bleaching products with high-concentration hydrogen peroxide (HP, 30-40%) are effective but detrimental due to the increased risk of enamel destruction, tooth sensitivity, and gingival irritation. Herein, we reported a less-destructive and efficient tooth whitening strategy with a low-concentration HP, which was realized by the remarkably enhanced Fenton-like catalytic activity of oxygen-deficient TiO2 (TiO2-x). TiO2-x nanoparticles were synthesized with a modified solid-state chemical reduction approach with NaBH4. The Fenton-like activity of TiO2-x was optimized by manipulating oxygen vacancy (OV) concentration and further promoted by the near-infrared (NIR)-induced photothermal effect of TiO2-x. The TiO2-x sample named BT45 was chosen due to the highest methylene blue (MB) adsorption ability and Fenton-like activity among acquired samples. The photothermal property of BT45 under 808 nm NIR irradiation was verified and its enhancement on Fenton-like activity was also studied. The BT45/HP + NIR group performed significantly better in tooth whitening than the HP + NIR group on various discolored teeth (stained by Orange II, tea, or rhodamine B). Excitingly, the same tooth whitening performance as the Opalescence Boost, a tooth bleaching product containing 40% HP, was obtained by a self-produced bleaching gel based on this novel system containing 12% HP. Besides, negligible enamel destruction, safe temperature range, and good cytocompatibility of TiO2-x nanoparticles also demonstrated the safety of this tooth bleaching strategy. This work indicated that the photothermal-enhanced Fenton-like performance of the TiO2-x-based system is highly promising in tooth bleaching application and can also be extended to other biomedical applications.