Proteomic Studies on the Development of the Central Nervous System and Beyond
Proteomic Studies on the Development of the Central Nervous System and Beyond
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DOI：
10.1007/s11064-010-0218-z
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发表时间：
2010-06
影响因子：
4.4
通讯作者：
Cheng-gang Zhang
中科院分区：
文献类型：
--
作者：
Cheng-gang Zhang
神经蛋白质组学已成为后基因组时代神经科学家的一个“象征”甚至“标志”。在过去的几十年中，许多蛋白质组学方法已被广泛用于破译大脑的复杂性，包括人类或非人类动物大脑发育的胚胎阶段的研究。蛋白质组学技术的使用带来了巨大的科学进步，包括使用2D-DIGE、ICAT和iTRAQ对蛋白质组学数据进行定量分析。此外，脑的蛋白质组学研究已扩展到亚蛋白质组学、突触蛋白质组学、神经质膜蛋白质组学甚至线粒体蛋白质组学等领域。在这一领域取得的快速进展不仅将增加基于发育中大脑的神经蛋白质组学的知识，而且还有助于增加对人类神经系统疾病的理解。本文将重点介绍中枢神经系统蛋白质组学研究，特别是脑发育蛋白质组学研究，以总结这一快速发展领域的研究进展。
Neuroproteomics has become a ‘symbol’ or even a ‘sign’ for neuroscientists in the post-genomic era. During the last several decades, a number of proteomic approaches have been used widely to decipher the complexity of the brain, including the study of embryonic stages of human or non-human animal brain development. The use of proteomic techniques has allowed for great scientific advancements, including the quantitative analysis of proteomic data using 2D-DIGE, ICAT and iTRAQ. In addition, proteomic studies of the brain have expanded into fields such as subproteomics, synaptoproteomics, neural plasma membrane proteomics and even mitochondrial proteomics. The rapid progress that has been made in this field will not only increase the knowledge based on the neuroproteomics of the developing brain but also help to increase the understanding of human neurological diseases. This paper will focus on proteomic studies in the central nervous system and especially those conducted on the development of the brain in order to summarize the advances in this rapidly developing field.