Effects of industrial noise exposure on distortion product otoacoustic emissions (DPOAEs) and hair cell loss of the cochlea - long term experiments in awake guinea pigs
Effects of industrial noise exposure on distortion product otoacoustic emissions (DPOAEs) and hair cell loss of the cochlea - long term experiments in awake guinea pigs
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DOI：
10.1016/s0378-5955(00)00101-5
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发表时间：
2000-10-01
期刊：
影响因子：
2.8
通讯作者：
Linss, W
中科院分区：
文献类型：
--
作者：
Emmerich, E;Richter, F;Linss, W
在12只清醒的豚鼠暴露于特定的回放工业噪声（最大强度105 dB SPL）前后2小时，监测了畸变产物耳声发射（dpoae）、外毛细胞（OHC）功能的敏感检测器、耳蜗微音（CM）和毛细胞损失。所有动物在噪声暴露前都有稳定的DPOAE水平。在噪声暴露后的最初几个小时内，DPOAE水平显著降低。约有70%的个案在接触噪音后4个月内部分恢复。在16%的被调查耳朵中，没有观察到dpoae的恢复。然而，在少数耳中，观察到噪声暴露后dpoae增加。暴露于工业噪声中会引起耳蜗中匝的形态变化和中频范围的电生理变化。DPOAE水平降低、CM电位损失与耳蜗损伤或损失的OHCs面积密切相关，但与耳蜗损伤或损失的OHCs数量无关。结果表明，连续工业噪声对OHCs的损伤不同于脉冲噪声对OHCs的损伤。(C) 2000 Elsevier Science B.V.版权所有
Distortion product otoacoustic emissions (DPOAEs), a sensitive detector of outer hair cell (OHC) function, cochlear microphonics (CM), and hair cell loss have been monitored in 12 awake guinea pigs before and after 2 h exposure to specific, played-back industrial noise (105 dB SPL maximal intensity). All animals had stable DPOAE levels before noise exposure. In the first hours after noise exposure DPOAE levels were reduced significantly. In about 70% a partial recovery of the DPOAEs was found within 4 months after noise exposure. In 16% of the investigated ears no recovery of DPOAEs was observed. However, in a few ears increased DPOAEs were observed after noise exposure. Exposure to industrial noise caused both morphological changes in the middle turns of the cochlea and electrophysiological changes in the middle frequency range. A close correlation existed between reduced DPOAE levels, loss in CM potentials, and area of damaged or lost OHCs, but not with the numbers of damaged or lost OHCs in the cochlea. It can be concluded that continuous industrial noise causes a damage to OHCs which differs form the damage caused by impulse noise. (C) 2000 Elsevier Science B.V. All rights reserved.