Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries
Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries
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DOI：
10.1177/154405910508401109
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发表时间：
2005-11-01
影响因子：
7.6
通讯作者：
Park, YK
中科院分区：
文献类型：
--
作者：
Koo, H;Schobel, B;Park, YK
芹菜素（API）和tt-法尼醇（Far）是两种天然存在的影响致龋生物膜发展的物质。氟化物（F）在物理化学上干扰龋齿的发展，也表现出抗菌活性。我们研究了API和Far的联合是否通过协同作用于变形链球菌毒力的表达来增强F的抗龋特性。当与F.一般而言，用API和/或Far与F组合处理的生物膜显示出比单独用测试试剂处理的生物膜更少的生物量和更少的不溶性葡聚糖和亲碘多糖（P < 0.05）。测试试剂与F的组合在预防大鼠龋齿发展方面非常有效，尤其是API+Far+F，并且结果与用氯己定+ F（阳性对照）观察到的结果相当。这些研究的结果表明芹菜素和tt-法尼醇可以增强氟化物的防龋效果。
Apigenin (Api) and tt-farnesol (Far) are two naturally occurring agents that affect the development of cariogenic biofilms. Fluoride (F) interferes physicochemically with caries development and also exhibits antibacterial activity. We examined whether the association of Api and Far enhance the anti-caries properties of F by acting cooperatively on the expression of virulence of Streptococcus mutans. The biological effects of each of the agents were greatly enhanced when used in combination with F. In general, biofilms treated with Api and/or Far in combination with F displayed less biomass and fewer insoluble glucans and iodophilic polysaccharides than did those treated with the test agents alone (P < 0.05). The combination of the test agents with F was highly effective in preventing caries development in rats, especially Api+Far+F, and results were comparable with those observed with chlorhexidine + F (positive control). Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride.