Sensorineural hearing loss: potential therapies and gene targets for drug development.
Sensorineural hearing loss: potential therapies and gene targets for drug development.
复制标题
感音神经性听力损失：药物开发的潜在疗法和基因靶点。
DOI：
10.1080/15216540600913258
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发表时间：
2006
期刊：
影响因子：
4.6
通讯作者：
Pereira,FredA
中科院分区：
文献类型：
--
作者：
Tang,LouisaS;Montemayor,Celina;Pereira,FredA
内耳发育生物学、遗传学和细胞生物学的最新进展正在引导研究新的治疗方式-目前估计市场至少为100亿美元。本文重点介绍了通过基因和干细胞递送到内耳来保护、修复或再生毛细胞、支持细胞和相关神经来操纵哺乳动物听觉器官的前景。iubmb Life，58：525 - 530，2006年
Recent advances in the developmental biology, genetics and cell biology of the inner ear are guiding research to novel therapeutic modalities ‐ a market currently estimated to be at least US$10 billion. This article highlights prospects to manipulate the mammalian hearing organ with gene and stem cell delivery to the inner ear to protect, repair or regenerate the hair cells, supporting cells and associated nerves. iubmb Life, 58: 525‐530, 2006