Cutaneous manifestations of Mycobacterium gordonae infection described for the first time in Italy: a case report.
Cutaneous manifestations of Mycobacterium gordonae infection described for the first time in Italy: a case report.
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DOI：
10.1186/1757-1626-0002-0000006828
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发表时间：
2009-07-31
期刊：
影响因子：
--
通讯作者：
Angelini, Giovanni
中科院分区：
文献类型：
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作者：
Foti, Caterina;Sforza, Vincenza;Angelini, Giovanni
简介：gordonae分枝杆菌是致病性最低的分枝杆菌之一。该病原体可产生干酪化或非干酪化肉芽肿，皮肤病变表现为急性或慢性炎症，伴有分散的组织细胞和巨细胞。死亡率低于0.1%。gordonae分支杆菌可能是人类免疫缺陷病毒感染患者严重免疫抑制的标志。病例介绍：我们报告一例戈登分枝杆菌感染在一个86岁的妇女和讨论固有的问题，以识别和治疗这种新出现的病原体。我们分离的gordonae分枝杆菌菌株对甲氧苄啶-磺胺甲恶唑耐药，但对环丙沙星敏感，长期给药（6个月）可诱导皮肤脓肿完全愈合。结论：先进的实验室诊断技术提高了非结核分枝杆菌的分离和鉴定水平。诊断需要很高的临床怀疑指数，因为用常规方法检测是困难的。据我们所知，该患者是意大利第一例皮肤感染该病原体的病例。
INTRODUCTION: Mycobacterium gordonae is one of the least pathogenic of the mycobacteria. This pathogen may produce caseating or non-caseating granulomas, and skin lesions showing acute or chronic inflammation with scattered histiocytes and giant cells have been seen. The mortality rate is less than 0.1%. Mycobacterium gordonae may be a marker of severe immunosuppression in patients infected with human immunodeficiency virus.CASE PRESENTATION: We report a case of Mycobacterium gordonae infection in an 86-year-old woman and discuss the problems inherent to the identification and treatment of this emerging pathogen. Mycobacterium gordonae strain we isolated was resistant to trimethoprim-sulfamethoxazole but sensitive to ciprofloxacin, and long term administration (six months) induced complete healing of the cutaneous abscesses.CONCLUSION: Advanced laboratory diagnostic techniques have improved the isolation and identification of nontuberculous mycobacteria. The diagnosis requires a high index of clinical suspicion, as detection by conventional methods is difficult. To our knowledge, this patient is the first documented case of cutaneous infection from this pathogen in Italy.