Macrophages and translymphatic absorption represent the first line of host defense of the peritoneal cavity.
Macrophages and translymphatic absorption represent the first line of host defense of the peritoneal cavity.
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DOI：
10.1001/archsurg.1987.01400130111017
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发表时间：
1987
影响因子：
--
通讯作者：
D. Dunn;R. Barke;D. Ewald;R. L. Simmons
中科院分区：
文献类型：
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作者：
D. Dunn;R. Barke;D. Ewald;R. L. Simmons
为了定量大鼠腹腔的宿主防御，腹膜内注射不能存活的放射性标记的大肠杆菌，并检查清除、白细胞流入和吞噬作用。巨噬细胞（MC）最初存在并且数量保持相对恒定。多形核白细胞 (PMN) 反应在 1 至 2 小时内开始，并在 24 至 72 小时内达到最大。定义了先前未识别的依赖于接种物的 PMN 反应。清除和吞噬作用极其迅速，两小时后几乎没有（小于 3%）游离细菌存在。 MC 和 PMN 的吞噬活性相同，但 MC 最初在数量上占主导地位，因此占早期吞噬作用的大部分。因此，MC 吞噬作用和清除作用代表宿主腹膜防御的主要防线。我们假设随后的接种物依赖性 PMN 反应可能已经进化到能够应对那些初始反应不足的较大接种物。
To quantitate the host defenses of the rat peritoneal cavity, nonviable radiolabeled Escherichia coli were injected intraperitoneally and clearance, leukocyte influx, and phagocytosis were examined. Macrophages (MCs) were present initially and remained relatively constant in number. The polymorphonuclear leukocyte (PMN) response began at one to two hours and was maximal at 24 to 72 hours. A previously unidentified inoculum-dependent PMN response was defined. Clearance and phagocytosis were extremely rapid, and few (less than 3%) free bacteria were present after two hours. Phagocytic activity of MCs and PMNs was identical, but MCs were numerically predominant initially and thus accounted for the majority of early phagocytosis. Thus, MC phagocytosis and clearance represent the primary line of host peritoneal defenses. We hypothesize that the subsequent inoculum-dependent PMN response may have evolved to cope with those larger inocula for which this initial response is inadequate.