Perspectives of US women participating in a candidate PrEP study: adherence, acceptability and future use intentions
Perspectives of US women participating in a candidate PrEP study: adherence, acceptability and future use intentions
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DOI：
10.1002/jia2.25247
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发表时间：
2019-03-01
影响因子：
6
通讯作者：
Adimora, Adaora A.
中科院分区：
文献类型：
--
作者：
Amico, K. Rivet;Ramirez, Catalina;Adimora, Adaora A.
引言：关于美国女性中候选暴露前预防（PrEP）方案的可接受性的数据有限。我们评估了PrEP的经验，态度和未来的使用意向性活跃的妇女谁完成了美国的艾滋病毒预防试验网络069/艾滋病临床试验组5305 study.Methods：妇女参加了2013年3月至2015年11月的研究。我们分析了130名妇女的计算机辅助自我访谈（CASI）调查，并对来自三个地点的26名妇女进行了深入访谈。结果：大多数女性（57%）报告对CASI的PrEP依从性非常好/优秀，尽管21%的人承认至少在某些时候过度报告依从性。致力于预防艾滋病毒感染，对研究的主人翁感，以及将药丸储存在可见的位置有助于坚持。坚持的障碍包括“简单的忘记”和离家出走。大多数接受采访的妇女不打算在未来使用PrEP，因为她们自己缺乏感知需要。（而不是他们的伴侣的）低风险行为和对负担能力的担忧--但不是因为副作用或方案的其他特点。改善美国妇女的艾滋病毒预防选择将需要获得负担得起的PrEP以及扩大妇女对关系的理解-以及增加他们感染艾滋病毒风险的社区因素。
Introduction: Limited data exist on acceptability of candidate pre-exposure prophylaxis (PrEP) regimens among US women. We evaluated PrEP experiences, attitudes and future use intentions among sexually active women who completed the US-based HIV Prevention Trials Network 069/AIDS Clinical Trials Group 5305 study.Methods: Women participated in the study between March 2013 and November 2015. We analysed computer-assisted self-interview (CASI) surveys among 130 women and conducted in-depth interviews among a subset of 26 women from three sites. Interviews were conducted in mid/late-2015.Results: Most women (57%) reported very good/excellent PrEP adherence on CASI, although 21% acknowledged over-reporting adherence at least some of the time. Commitment to preventing HIV infection, a sense of ownership of the study, and keeping pills stored in a visible location facilitated adherence. Adherence barriers included "simply forgetting" and being away from home. Most women interviewed did not intend to use PrEP in the future because of lack of perceived need due to their own (as opposed to their partners') low-risk behaviour and concerns about affordability - but not because of side effects or other characteristics of the regimens.Conclusions: Improving HIV prevention options for US women will require access to affordable PrEP as well as expanding women's understanding of relationship- and community-level factors that increase their risk of acquiring HIV.