Inositol phosphates turnover, cytosolic Ca++ and pH: putative signals for the control of cell growth.
Inositol phosphates turnover, cytosolic Ca++ and pH: putative signals for the control of cell growth.
复制标题
磷酸肌醇周转、胞质 Ca 和 pH：控制细胞生长的推定信号。
DOI：
10.1016/0024-3205(86)90632-6
复制
发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Villereal,ML
中科院分区：
文献类型：
--
作者：
Vicentini,LM;Villereal,ML
The signals that induce a cell to divide are usually external and in the form of a binding of growth factors. We focussed our attention in defining the sequence of events which occurs after the binding of the mitogens to their surface receptors. One of the early membrane events stimulated by growth factors is a Na+ flux coupled to a H+ efflux that is typically inhibited by amiloride. The importance of this event and of the consequent cytoplasmic alkalinization for the cell proliferation is discussed. Recent data indicate that mitogens increase intracellular Ca++ levels and activate protein kinase C by inducing the hydrolysis of membrane phosphoinositides. A role for Ca++ and protein kinase C in activating Na+ H+ exchange system is discussed. Finally a model is presented that illustrates the first membrane events stimulated by the growth factors. The model reveals an intimate interconnections between phosphoinositide metabolism, crtosolic Ca++ rise, protein kinase C and cytoplasmic alkalinization.
