FGFR1 is required for the development of the auditory sensory epithelium
FGFR1 is required for the development of the auditory sensory epithelium
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DOI：
10.1016/s0896-6273(02)00824-3
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发表时间：
2002-08-15
期刊：
影响因子：
16.2
通讯作者：
Partanen, J
中科院分区：
文献类型：
--
作者：
Pirvola, U;Ylikoski, J;Partanen, J
哺乳动物的听觉上皮是Corti的器官，由对听力功能至关重要的毛细胞和支持细胞组成。人们对其前体的起源和发展知之甚少。在这里，我们表明，小鼠成纤维细胞生长因子受体1(FGFR1)功能缺失突变会导致剂量依赖性的Corti器官破坏。FOXG1-CRE介导的缺失使内耳上皮中FGFR1完全失活，导致听觉毛细胞数量减少85%。主要原因似乎是早期耳蜗管中的前体细胞增殖减少。因此，在发育过程中，FGFR1是产生前体细胞池所必需的，而前体细胞池产生了听觉感觉上皮。我们的数据还表明，FGFR1可能在分化的听觉感觉上皮细胞内的细胞间信号转导中起着明显的后期作用。
The mammalian auditory sensory epithelium, the organ of Corti, comprises the hair cells and supporting cells that are pivotal for hearing function. The origin and development of their precursors are poorly understood. Here we show that loss-of-function mutations in mouse fibroblast growth factor receptor 1 (Fgfr1) cause a dose-dependent disruption of the organ of Corti. Full inactivation of Fgfr1 in the inner ear epithelium by Foxg1-Cre-mediated deletion leads to an 85% reduction in the number of auditory hair cells. The primary cause appears to be reduced precursor cell proliferation in the early cochlear duct. Thus, during development, FGFR1 is required for the generation of the precursor pool, which gives rise to the auditory sensory epithelium. Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium.