RELATIONSHIP OF AGE-RELATED DECLINE ACROSS SEVERAL BEHAVIORAL DOMAINS
RELATIONSHIP OF AGE-RELATED DECLINE ACROSS SEVERAL BEHAVIORAL DOMAINS
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DOI：
10.1016/0197-4580(89)90006-7
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发表时间：
1989-11-01
影响因子：
4.2
通讯作者：
BURWELL, RD
中科院分区：
文献类型：
--
作者：
GALLAGHER, M;BURWELL, RD
这些研究旨在评估老年大鼠在许多行为任务中是否有相似程度的损伤。在实验1中，老年大鼠空间障碍的严重程度与反应时间表现没有关系。这一结果与在老年大鼠中发现的空间学习与味觉新恐惧症恢复率之间的关系形成对比（实验2和3的结果）。实验3进一步表明，老年大鼠“受损”和“未受损”两个亚组的相对空间学习能力与原训练完成6周后进行的水迷宫转移训练有关。老年动物的亚组也通过它们在圆孔板迷宫上的潜伏期（但不是错误）和在整个方案结束时（测试的第13周）确定的光/暗循环期间的水消耗模式来区分。然而，其他的测量方法并不能区分基于空间学习能力形成的老年亚组。
These studies were designed to assess whether aged rats have a similar degree of impairment across a number of behavioral tasks. In Experiment 1, no relationship between the severity of a spatial impairment and reaction time performance was found among aged rats. This result is in contrast with a relationship that was found in aged rats between spatial learning and the rate of recovery from gustatory neophobia (results of Experiments 2 and 3). Experiment 3 further showed that the relative spatial learning abilities of two subgroups of aged rats, i.e., "impaired" and "unimpaired," were related to transfer training in the water maze conducted six weeks after the completion of original training. The subgroups of aged animals were also distinguished by their latencies (but not errors) on a circular holeboard maze, and the pattern of water consumption during the light/dark cycle determined at the end of the entire protocol (13th week of testing). Other measures, however, did not distinguish the aged subgroups that were formed on the basis of spatial learning ability.