A case-control study on the relationship of hearing function and blood concentrations of lead, manganese, arsenic, and selenium
A case-control study on the relationship of hearing function and blood concentrations of lead, manganese, arsenic, and selenium
复制标题
DOI：
10.1016/j.scitotenv.2007.07.032
复制
发表时间：
2007-11-15
影响因子：
9.8
通讯作者：
Wu, Trong-Neng
中科院分区：
文献类型：
--
作者：
Chuang, Hung-Yi;Kuo, Ching-Hsia;Wu, Trong-Neng
先前的研究表明，重金属可能对人类有耳毒性，而且，当微量元素硒存在时，这种毒性可能会通过形成金属硒化物复合物而发生逆转。本研究以294名在高雄医科大学附属医院接受定期职业健康检查的病患为研究对象，进行病例对照研究。所有对照受试者（n = 173）听力正常。病例受试者（n = 121）平均听力阈值超过25分贝（dB）。采用ICP-MS和标准方法测定所有个体血铅（Pb）、锰（Mn）、砷（As）和硒（Se）浓度。通过问卷调查和病史回顾收集可能的混杂因素。采用多元线性回归和混合模型分析关系。测定病例组（107.2、5.5、17.8和229.1 mu g/L）和对照组（38.9、5.4、15.5和234.4 mu g/L）的Pb、Mn、As和Se的几何平均值。在我们的回归模型中，年龄、铅和硒浓度（对数转换）与听力阈值显著相关。此外，我们发现硒与听力阈值呈负相关，并且可能是铅耳毒性的拮抗剂。在多重回归中调整了其他潜在的混杂因素后，本研究证明了血铅和听力阈值之间的剂量-反应关系。此外，我们发现硒可能是听觉功能的保护元素。然而，需要进一步的研究来阐明铅毒性和硒在分子和遗传水平上对听力功能的影响机制。(C) 2007 Elsevier B.V.版权所有
Previous research has suggested that heavy metals may be ototoxic in humans, and further, that a reversal of this toxicity may occur when the trace element selenium is present, through formation of metals selenide complexes. This study investigates the relationship between hearing thresholds and blood concentrations of four elements (selenium, lead, manganese, and arsenic) in factory workers, Taiwan. We conducted a hospital-based case-control study with 294 individuals who received the periodic occupational health examination in the Kaohsiung Medical University Hospital. All control subjects (n = 173) had normal hearing. Case subjects (n = 121) had average hearing threshold over 25 decibels (dB). In all individuals, blood concentrations of lead (Pb), manganese (Mn), arsenic (As), and selenium (Se) were determined by an ICP-MS and standard methods. Possible confounding factors were collected by a questionnaire and medical history reviews. Relationships were analyzed by multiple linear regressions and mixed model. Geometric means of Pb, Mn, As, and Se were determined for case subjects (107.2, 5.5, 17.8, and 229.1 mu g/L) and controls (38.9, 5.4, 15.5, and 234.4 mu g/L). In our regression models, age, lead and selenium concentrations (logarithmic transformed) were associated significantly with hearing thresholds. In addition, we found that the selenium was inversely associated with hearing thresholds, and may be an antagonist to lead ototoxicty. The present study demonstrated a dose-response relationship between blood lead and hearing thresholds, after adjusting other potential confounders in multiple regressions. In addition, we found that selenium may be a protection element on auditory function. However, additional studies will be needed to clarify the mechanisms of lead toxicity and selenium on the hearing function in molecular and genetic levels. (C) 2007 Elsevier B.V. All rights reserved.