MSCRAMM--targeted vaccines and immunotherapy for staphylococcal infection.
MSCRAMM--targeted vaccines and immunotherapy for staphylococcal infection.
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发表时间：
2004-03
影响因子：
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通讯作者：
J. M. Rivas;P. Speziale;J. Patti;M. Höök
中科院分区：
文献类型：
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作者：
J. M. Rivas;P. Speziale;J. Patti;M. Höök
医院获得性感染与住院时间延长以及医疗费用和资源增加有关。复杂医疗程序的进步、免疫功能低下患者数量的增加以及对常规抗生素治疗的耐药性的持续出现，已经产生了对预防和治疗感染性细菌疾病的替代策略的需求。针对微生物表面成分识别粘附基质分子（MSCRAMM）蛋白的免疫预防和免疫治疗是可能阻碍细菌粘附、消除定植和最小化血行播散的可行方法，从而阻止感染的发生和进展。本文综述了几项研究工作，其中葡萄球菌MSCRAMM蛋白被用于亚单位疫苗的设计和创新的治疗策略，可以实施感染后，管理严重和危及生命的疾病的发展。
Hospital-acquired infections are associated with prolonged hospitalization and an increase in both healthcare costs and resources. Advances in sophisticated medical procedures, an increase in the number of immunocompromised patients, and the continued emergence of resistance to conventional antibiotic therapy has created a need for alternative strategies to prevent and treat infectious bacterial diseases. Immunoprevention and immunotherapy targeting microbial surface components recognizing adhesive matrix molecule (MSCRAMM) proteins are viable approaches to potentially impede bacterial adherence, eliminate colonization, and minimize hematogenous dissemination, thereby halting the inception and progression of infection. This review summarizes several investigative efforts where staphylococcal MSCRAMM proteins are being utilized in the design of subunit vaccines and in the development of innovative therapeutic strategies that could be implemented following the onset of infection to manage severe and life-threatening disease.