Glaucoma Diagnostic Accuracy of Ganglion Cell-Inner Plexiform Layer Thickness: Comparison with Nerve Fiber Layer and Optic Nerve Head
Glaucoma Diagnostic Accuracy of Ganglion Cell-Inner Plexiform Layer Thickness: Comparison with Nerve Fiber Layer and Optic Nerve Head
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DOI：
10.1016/j.ophtha.2011.12.014
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发表时间：
2012-06-01
期刊：
影响因子：
13.7
通讯作者：
Crandall, Alan S.
中科院分区：
文献类型：
--
作者：
Mwanza, Jean-Claude;Durbin, Mary K.;Crandall, Alan S.
目的：确定使用 Cirrus 高清光学相干断层扫描 (HD-OCT) 神经节细胞分析 (GCA) 算法（Carl Zeiss Meditec，都柏林，加利福尼亚州）测量的黄斑神经节细胞内丛状层 (GCIPL) 厚度的诊断性能，以区分正常眼睛和早期青光眼眼睛，并将其与视乳头周围视网膜神经纤维层 (RNFL) 厚度和设计：诊断测试或技术的评估。参与者：58 名早期青光眼患者和 99 名年龄匹配的正常受试者。方法：测量每位参与者的黄斑 GCIPL 和视乳头周围 RNFL 厚度和 ONH 参数，并比较他们的诊断能力。主要结果测量：接受者操作特征的曲线下面积（AUC）。结果：最佳的 GCIPL 参数AUC 分别为最小值（0.959）、颞下区（0.956）、平均区（0.935）、颞上区（0.919）和下区（0.918）。这些 AUC 与下象限 (0.939)、平均 (0.936) 和上象限 RNFL (0.933) 之间没有显着差异；垂直杯盘直径比（0.962）；杯盘面积比（0.933）；和边缘面积（0.910），均 P>0.05。结论：黄斑 GCIPL 参数区分正常眼和早期青光眼眼的能力较高，与最佳视乳头周围 RNFL 和 ONH 参数相当。 财务披露：专有或商业披露可在参考文献后找到。眼科 2012 年；119:1151-1158 (C) 2012 年，美国眼科学会。
Purpose: To determine the diagnostic performance of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured with the Cirrus high-definition optical coherence tomography (HD-OCT) ganglion cell analysis (GCA) algorithm (Carl Zeiss Meditec, Dublin, CA) to discriminate normal eyes and eyes with early glaucoma and to compare it with that of peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements.Design: Evaluation of diagnostic test or technology.Participants: Fifty-eight patients with early glaucoma and 99 age-matched normal subjects.Methods: Macular GCIPL and peripapillary RNFL thicknesses and ONH parameters were measured in each participant, and their diagnostic abilities were compared.Main Outcome Measures: Area under the curve (AUC) of the receiver operating characteristic.Results: The GCIPL parameters with the best AUCs were the minimum (0.959), inferotemporal (0.956), average (0.935), superotemporal (0.919), and inferior sector (0.918). There were no significant differences between these AUCs and those of inferior quadrant (0.939), average (0.936), and superior quadrant RNFL (0.933); vertical cup-to-disc diameter ratio (0.962); cup-to-disc area ratio (0.933); and rim area (0.910), all P>0.05.Conclusions: The ability of macular GCIPL parameters to discriminate normal eyes and eyes with early glaucoma is high and comparable to that of the best peripapillary RNFL and ONH parameters.Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. Ophthalmology 2012;119:1151-1158 (C) 2012 by the American Academy of Ophthalmology.