Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children
Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children
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DOI：
10.1111/j.1399-3046.2007.00780.x
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发表时间：
2007-11-01
影响因子：
1.3
通讯作者：
Ma, Yuanfang
中科院分区：
文献类型：
--
作者：
Fang, Baijun;Song, Yongping;Ma, Yuanfang
严重的GVHD是ASCT的致命并发症，因此许多方法正在评估中。最近，勒布朗等人。报道了一例肠和肝脏的IV级耐药急性移植物抗宿主病，在输注间充质干细胞后迅速改善。在这里，我们描述了两名儿童患者，他们在ASCT后发展为严重的难治性急性移植物抗宿主病，并成功地接受了来自不相合的非亲缘供者的AMSC治疗。
Severe GVHD is a lethal complication to ASCT, and a number of approaches are therefore being evaluated. Recently, Le Blanc et al. reported a case of grade IV therapy-resistant acute GVHD of the gut and liver that showed rapid improvement after infusion of mesenchymal stem cells. Here we describe two pediatric patients who developed severe refractory acute GVHD following ASCT and were successfully treated with AMSC from HLA-mismatched unrelated donors.