Prepulse inhibition deficits in schizophrenia are modified by smoking status.
Prepulse inhibition deficits in schizophrenia are modified by smoking status.
复制标题
精神分裂症的前脉冲抑制缺陷会因吸烟状况而改变。
DOI：
10.1016/j.schres.2009.04.016
复制
发表时间：
2009
影响因子：
4.5
通讯作者：
George,TonyP
中科院分区：
文献类型：
--
作者：
Woznica,AndreaA;Sacco,KristiA;George,TonyP
背景精神分裂症与高吸烟率和感觉运动门控缺陷有关，通过惊吓反应的前脉冲抑制（PPI）来测量。然而，PPI 缺陷与吸烟状况之间的关系尚不清楚。我们检查了吸烟状况是否改变了精神分裂症中的 PPI 缺陷。 方法我们采用横断面设计，在四组中研究了 PPI 作为吸烟状况和精神分裂症诊断的函数：患有精神分裂症的吸烟者 (SS; n=14)、患有精神分裂症的非吸烟者 (SNS; n=15)、吸烟对照者 (CS; n=11) 和非吸烟对照者（中枢神经系统；n=10）。在吸烟饱足条件下记录吸烟者的PPI，并通过生化验证吸烟状况。结果诊断×吸烟状况×前脉冲间隔交互作用显着（F11，140=5.01，p<0.001）。在所有预脉冲到脉冲间隔（PPTPI；30、60 和 120 ms）中，我们发现与 CNS 相比，SNS 的 PPI 降低了（约 50%；p<0.01）。然而，当在吸烟饱足条件下将 SS 与 CS 进行比较时，SS 的 PPI 水平与 CS 相当，并且 PPI 水平显着高于 SNS。结论我们的研究结果表明，PPI 缺陷存在于非吸烟精神分裂症患者中，并且可能会因吸烟状况而改变。精神分裂症患者急性吸烟与 PPI 升高至非精神控制吸烟者的水平有关。这些发现对于了解精神分裂症患者对烟草依赖的脆弱性具有重要意义，这可能会导致针对该人群的 PPI 缺乏和烟草依赖开发更有效的治疗方法。
BACKGROUNDSchizophrenia is associated with high rates of cigarette smoking and deficits in sensorimotor gating, as measured by prepulse inhibition (PPI) of the startle response. However, the relationship between PPI deficits and smoking status is unclear. We examined whether smoking status modifies PPI deficits in schizophrenia.METHODSWe studied PPI as a function of smoking status and schizophrenia diagnosis in four groups using a cross-sectional design: Smokers with schizophrenia (SS; n=14), non-smokers with schizophrenia (SNS; n=15), control smokers (CS; n=11), and control non-smokers (CNS; n=10). PPI in smokers was recorded under conditions of smoking satiation, and smoking status was verified biochemically.RESULTSThe Diagnosis×Smoking Status×Prepulse Interval interaction was significant (F11,140=5.01, p<0.001). At all prepulse to pulse intervals (PPTPIs; 30, 60 and 120 ms), we found that SNS had reductions (~50%; p<0.01) in PPI compared to CNS. However, when SS were compared to CS under conditions of smoking satiation, SS had comparable levels of PPI to CS, and significantly higher levels of PPI than SNS.CONCLUSIONSOur findings suggest that PPI deficits are present in nonsmokers with schizophrenia, and may be modified by smoking status. Acute smoking in schizophrenia is associated with an elevation of PPI to the levels in non-psychiatric control smokers. These findings have significant implications for understanding vulnerability to tobacco dependence in schizophrenia, which may lead to the development of more effective treatments for PPI deficits and tobacco dependence in this population.