Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease.
Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease.
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DOI：
10.1016/j.bbadis.2015.10.014
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Iliff JJ
中科院分区：
文献类型：
--
作者：
Simon MJ;Iliff JJ
脑脊液（CSF）的循环和周转为消除脑间质中的溶质提供了一个水池，对中枢神经系统的功能起着重要的稳态作用。正常脑脊液循环和转换的中断被认为是许多疾病的发生的原因，包括神经退行性疾病，如阿尔茨海默病、缺血性和创伤性脑损伤，以及神经炎性疾病，如多发性硬化症。最近对脑脊液生物学的研究表明，脑脊液和间质液交换沿着被称为“淋巴”系统的全脑血管周围空间网络进行，这表明脑脊液循环可能与神经胶质和血管功能密切相互作用，以调节脑功能的基本方面。这种神经胶质血管网络的功能障碍是衰老和脑损伤的一个特征，是脑损伤、神经炎症和慢性神经变性发展之间的潜在关键联系。该领域正在进行的研究可能为理解神经退行性疾病、神经血管疾病和神经炎症疾病之间的共同联系提供一个强有力的新框架，并为这些疾病提供潜在的新治疗靶点。
Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of solutes from the brain interstitium, serving an important homeostatic role for the function of the central nervous system. Disruption of normal CSF circulation and turnover is believed to contribute to the development of many diseases, including neurodegenerative conditions such as Alzheimer’s disease, ischemic and traumatic brain injury, and neuroinflammatory conditions such as multiple sclerosis. Recent insights into CSF biology suggesting that CSF and interstitial fluid exchange along a brain-wide network of perivascular spaces termed the ‘glymphatic’ system suggest that CSF circulation may interact intimately with glial and vascular function to regulate basic aspects of brain function. Dysfunction within this glial vascular network, which is a feature of the aging and injured brain, is a potentially critical link between brain injury, neuroinflammation and the development of chronic neurodegeneration. Ongoing research within this field may provide a powerful new framework for understanding the common links between neurodegenerative, neurovascular and neuroinflammatory disease, in addition to providing potentially novel therapeutic targets for these conditions.