SUNDAY START MULTIPHASIC ORAL CONTRACEPTION - OVULATION PREVENTION AND DELAYED FOLLICULAR ATRESIA IN PRIMATES
SUNDAY START MULTIPHASIC ORAL CONTRACEPTION - OVULATION PREVENTION AND DELAYED FOLLICULAR ATRESIA IN PRIMATES
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DOI：
10.1016/0010-7824(89)90064-4
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发表时间：
1989-03-01
期刊：
影响因子：
2.9
通讯作者：
HODGEN, GD
中科院分区：
文献类型：
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作者：
DANFORTH, DR;HODGEN, GD
利用“周日开始”方法进行口服避孕药治疗可以导致最迟在卵巢/月经周期的第 6 天开始口服避孕药。由于卵泡的快速进展，可能会发生“突破性”排卵，尤其是在雌激素-孕激素开始施用之前明显建立了优势卵泡的情况下。在这里，我们检查了两种新的口服避孕药方案对具有正常月经周期的食蟹猴在周期第 1 或 6 天开始的第一个治疗周期中潜在“突破”排卵的功效。我们的内分泌研究结果表明，卵泡募集以及可能的优势卵泡选择发生在卵泡期的第 6 天。两种口服避孕药治疗（Loestrin 5/7/99、LoDose 5/7/9R、Parke-Davis）均能有效阻止排卵前样促性腺激素和雌二醇激增以及黄体期黄体酮升高，无论治疗是在月经周期的第 1 天还是第 6 天开始。尽管激素证据表明成熟进展显着，但口服避孕药成功地阻止了卵泡成熟的完成，从而维持了避孕的可靠性，即使在使用“周日开始”方案的初始治疗周期中也是如此。在这些条件下，卵巢基质内失败的优势卵泡的溶解可能以延迟性卵泡闭锁为特征。
Utilization of the "sunday start" method for oral contraceptive therapy can result in the initiation of oral contraceptive administration as late as day 6 of the ovarian/menstrual cycle. Potentially, "breakthrough" ovulations could occur due to rapid follicular progression, especially if the dominant follicle is overtly established prior to the onset of estrogen-progestin administration. Here, we examined the efficacy of two new oral contraceptive regimens on potential "breakthrough" ovulations in the first cycle of treatment begun on cycle days 1 or 6 in cynomolgus monkeys having normal menstrual cycles. Our endocrine findings show that follicular recruitment, and probably selection of the dominant follicle, had occurred by day 6 of the follicular phase. Both oral contraceptive treatments (Loestrin 5/7/99, LoDose 5/7/9R, Parke-Davis) were effective in blocking preovulatory-like gonadotropin and estradiol surges as well as luteal phase progesterone elevations, whether treatment was begun on day 1 or day 6 of the menstrual cycle. Despite hormonal evidence of significant maturational progression, oral contraceptive administration successfully blocked the completion of follicular maturation, thereby sustaining contraceptive reliability, even in the initial cycle of treatment using a "sunday start" regimen. Under these conditions, dissolution of the failed dominant follicle within ovarian stroma may be characterized by delayed follicular atresia.