Monitoring blood coagulation with magnetoelastic sensors
Monitoring blood coagulation with magnetoelastic sensors
复制标题
DOI：
10.1016/s0956-5663(03)00033-2
复制
发表时间：
2003-05-01
影响因子：
12.6
通讯作者：
Bachas, LG
中科院分区：
文献类型：
--
作者：
Puckett, LG;Barrett, G;Bachas, LG
凝血时间的测定是监测治疗性抗凝剂的重要组成部分。用于测量血液凝固时间的标准方法需要专门的人员并且涉及血液采样程序。提出了一种基于磁弹性传感器的血液凝固监测新方法。带状磁致弹性传感器以基频振荡，该基频响应于所施加的质量负载或弹性变化的固定质量负载而线性地偏移。磁致弹性传感器发射磁通量，该磁通量可以由远程定位的拾取线圈检测到，因此不需要直接的物理连接。在血液凝固过程中，由于软纤维蛋白凝块的形成，血液的粘度发生变化。反过来，这种粘度的变化使磁致弹性传感器的特征共振频率偏移，从而能够实时连续监测这种生物事件。通过监测作为时间函数的信号输出，可以看到明显的血液凝固曲线。磁致弹性带的相对低的成本使得它们能够用作一次性传感器。这一点，沿着所需血量的减少，使得磁致弹性传感器非常适合于家庭和护理点测试设备。(C)2003 Elsevier Science B.V.保留所有权利。
The determination of blood coagulation time is an essential part of monitoring therapeutic anticoagulants. Standard methodologies for the measurement of blood clotting time require dedicated personnel and involve blood sampling procedures. A new method based on magnetoelastic sensors has been employed for the monitoring of blood coagulation. The ribbon-like magnetoelastic sensor oscillates at a fundamental frequency, which shifts linearly in response to applied mass loads or a fixed mass load of changing elasticity. The magnetoelastic sensors emit magnetic flux, which can be detected by a remotely located pick-up coil, so that no direct physical connections are required. During blood coagulation, the viscosity of blood changes due to the formation of a soft fibrin clot. In turn, this change in viscosity shifts the characteristic resonance frequency of the magnetoelastic sensor enabling real-time continuous monitoring of this biological event. By monitoring the signal output as a function of time, a distinct blood clotting profile can be seen. The relatively low cost of the magnetoelastic ribbons enables their use as disposable sensors. This, along with the reduced volume of blood required, make the magnetoelastic sensors well suited for at-home and point-of-care testing devices. (C) 2003 Elsevier Science B.V. All rights reserved.