A METALLOPROTEINASE INHIBITOR AS AN INHIBITOR OF NEOVASCULARIZATION
A METALLOPROTEINASE INHIBITOR AS AN INHIBITOR OF NEOVASCULARIZATION
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DOI：
10.1002/jcb.240470308
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发表时间：
1991-11-01
影响因子：
4
通讯作者：
LANGER, R
中科院分区：
文献类型：
--
作者：
MOSES, MA;LANGER, R
金属蛋白酶及其内源性抑制剂是酶系统的关键组成部分，该酶系统在许多基本生化和细胞过程中非常重要。 我们最近的工作重点是特定金属蛋白酶、胶原酶的作用，以及该酶的内源性抑制剂在控制新血管形成中的作用。 毛细血管内皮细胞（EC）对细胞外基质成分的蛋白水解降解已被证明是血管生成过程的关键先决条件之一。 作为胶原酶抑制对新生血管形成的影响研究的一部分，我们最近报道了体内和体外血管生成软骨源抑制剂 (CDI) 的纯化、表征和部分 NH2 末端序列。 有证据表明，控制许多“血管生成疾病”特征的失调血管生长的一种方法可能是在控制金属蛋白酶活性的水平上。
Metalloproteinases and their endogenous inhibitors are key components of an enzyme system which is important in a number of fundamental biochemical and cellular processes. Our recent work has focused on the role of a particular metalloproteinase, collagenase, and the role of an endogenous inhibitor of this enzyme in the control of neovascularization. The proteolytic degradation of extracellular matrix components by capillary endothelial cells (EC) has been shown to be one of the key prerequisites of the angiogenic process. As part of a study of the effect(s) of the inhibition of collagenase on neovascularization, we have recently reported the purification, characterization and partial NH2-terminal sequence of a cartilage-derived inhibitor (CDI) of angiogenesis in vivo and in vitro. Evidence is presented which suggests that one means of controlling deregulated vascular growth characteristic of a number of "angiogenic diseases" may be at the level of the control of metalloproteinase activity.