COMPARISON OF A TRANSFUSION PREPARATION OF NEWLY FORMED RED-CELLS AND STANDARD WASHED RED-CELL TRANSFUSIONS IN PATIENTS WITH HOMOZYGOUS BETA-THALASSEMIA
COMPARISON OF A TRANSFUSION PREPARATION OF NEWLY FORMED RED-CELLS AND STANDARD WASHED RED-CELL TRANSFUSIONS IN PATIENTS WITH HOMOZYGOUS BETA-THALASSEMIA
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DOI：
10.1046/j.1537-2995.1994.34694295068.x
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发表时间：
1994-06-01
期刊：
影响因子：
2.9
通讯作者：
OLIVIERI, NF
中科院分区：
文献类型：
--
作者：
COLLINS, AF;GONCALVESDIAS, C;OLIVIERI, NF
背景资料：以往的研究表明，输血的新形成的红细胞（neocytes）的患者与纯合子β-地中海贫血症的输血间隔适度延长研究设计和方法：一个新的系统的neocytepreparation（Neocel，刀具生物，伯克利，加利福尼亚州），报告联合收割机易于准备减少地中海贫血症患者的输血需求的临床效益进行了评估。16例接受脾切除术的地中海贫血患者接受了8次连续的标准自动洗涤红细胞输注（标准输注），随后接受了8次新生细胞输注（新生细胞输注）。在研究的每一组中，平均输血前血红蛋白和平均输注红细胞量都被仔细控制，并且是相似的。
Background: Previous studies of transfusions of newly formed red cells (neocytes) demonstrated modest extensions of transfusion interval in patients with homozygous beta-thalassemia.Study Design and Methods: The clinical benefits of a new system of neocyte preparation (Neocel, Cutter Biological, Berkeley, CA), reported to combine ease of preparation with reduction in the transfusion requirements of thalassemia patients, were evaluated. Sixteen thalassemic patients who had undergone splenectomy received eight consecutive, standard, automated, washed red cell transfusions (standard transfusions), followed by eight transfusions with the neocyte preparation (neocyte transfusions). In each arm of the study, mean pretransfusion hemoglobin and mean red cell mass transfused were carefully controlled and were similar.Results: A significant (p