Striatal Dopamine Responses to Intranasal Cocaine Self-Administration in Humans
Striatal Dopamine Responses to Intranasal Cocaine Self-Administration in Humans
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DOI：
10.1016/j.biopsych.2009.01.021
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发表时间：
2009-05-15
影响因子：
10.6
通讯作者：
Leyton, Marco
中科院分区：
文献类型：
--
作者：
Cox, Sylvia M. L.;Benkelfat, Chawki;Leyton, Marco
背景：在人类中，自我注射可卡因对细胞外多巴胺(DA)水平的影响尚未被测量。方法：10名非依赖可卡因使用者在鼻内注射盐酸可卡因(1.0 mg/kg)和安慰剂粉末后，进行了正电子发射断层扫描[C-11]雷氯普利扫描。结果：与安慰剂相比，鼻内注射可卡因降低了腹侧边缘纹状体和壳核的[C-11]拉氯普利结合值。结论：1)鼻腔给药可增加人纹状体突触DA的水平；2)街头使用兴奋剂与可卡因诱发的DA反应呈递增关系。这些多巴胺能效应可能影响对药物寻求行为的易感性和药物滥用的进展。
Background: The effect of self-administered cocaine on extracellular dopamine (DA) levels has not been measured in humans.Methods: Ten nondependent cocaine users underwent positron emission tomography [C-11]raclopride scans following intranasal self-administration of cocaine hydrochloride (1.0 mg/kg) and placebo powder.Results: Compared with placebo, intranasal cocaine self-administration decreased [C-11]raclopride binding values in the ventral limbic striatum and putamen. Individual differences in the magnitude of the [C-11]raclopride response in the ventral striatum were predicted by lifetime histories of stimulant drug use.Conclusions: The results suggest that 1) intranasal cocaine self-administration increases synaptic DA levels in human striatum and 2) prior use of stimulant drugs on the street is associated with progressively greater cocaine-induced DA responses. These dopaminergic effects might influence susceptibility to drug-seeking behavior and the progression to substance abuse.