The effect of inversion times on the minimum signal intensity of the contrast agent concentration using inversion recovery t1-weighted fast imaging sequence
The effect of inversion times on the minimum signal intensity of the contrast agent concentration using inversion recovery t1-weighted fast imaging sequence
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使用反转恢复 t1 加权快速成像序列反转时间对造影剂浓度最小信号强度的影响
DOI：
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发表时间：
2014
影响因子：
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通讯作者：
M. Nazarpoor
中科院分区：
文献类型：
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作者：
M. Nazarpoor
背景资料：反转恢复（IR）脉冲序列可以生成具有不同反转时间（TI）范围的T1加权图像，以抑制或消除指定组织的信号强度（SI）。在这项研究中，我们的目的是调查TI值对造影剂的浓度，这导致最小的信号强度，使用反转恢复T1加权三维快速梯度回波成像序列的影响。研究方法：体模设计为容纳25个小瓶，其中含有不同浓度（0和19.77 mmol/L之间的（Gd-DTPA））的造影剂。我们使用不同浓度的小瓶，使用具有不同反转时间（TI，100- 3000 ms）的IR序列来测量SI。结果：本研究的结果显示，对于较低的TI，T1恢复曲线不与x轴交叉。因此，可以从造影剂浓度对SI曲线观察到最小SI。本研究的结果还表明，导致最小SI的造影剂浓度取决于TI，TI浓度越高，最小SI越高。结论：总之，当TI参数用于抑制临床研究中指定组织的SI时（例如，灌注测量中的脂肪抑制或血液抑制），应非常谨慎地选择。
Background: Inversion recovery (IR) pulse sequences can generate T1-weighted images with a different range of inversion time (TI) to suppress or null the signal intensity (SI) for a specified tissue. In this study, we aimed to investigate the effect of TI values on the concentration of the contrast agent, which leads to a minimum signal intensity, using an inversion recovery T1-weighted 3-dimensional fast-gradient echo imaging sequence. Methods: A phantom was designed to hold 25 vials which contained different (between 0 and 19.77mmol/L of (Gd-DTPA)) concentrations of the contrast agent. We used the vials of different concentrations to measure SI using IR sequences with different inversion times (TI, 100-3000ms). Results: The results of this study revealed that the T1 recovery curve did not cross the x- axis for the lower TI. Therefore, a minimum SI can be observed from the concentration of the contrast agent versus SI curves. The findings of this study also revealed that the concentration of the contrast agent, which leads to a minimum SI, is dependent on the TI and the minimum SI will be increased at higher TI concentrations. Conclusion: In conclusion, when the TI parameter is used to suppress the SI of the specified tissues in clinical studies (e.g., fat suppression or blood suppression in perfusion measurements), it should be chosen with great caution.
影响因子：
24
作者：
Wagner, Anja;Mahrholdt, Heiko;Judd, Robert M.
通讯作者：
Judd, Robert M.