Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?
Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?
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DOI：
10.1093/gerona/gln065
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发表时间：
2009-02-01
影响因子：
5.1
通讯作者：
Vijg, Jan
中科院分区：
文献类型：
--
作者：
Campisi, Judith;Vijg, Jan
关于衰老的原因，最普遍的观点之一是，寿命在很大程度上受到大分子损伤的制约。在过去十年左右产生的越来越多的细胞和分子数据普遍支持这种衰老的“损伤累积”假说。关于哪些类型的损伤对驾驶老化最重要，仍有一些悬而未决的问题。此外，最近对损伤累积假说提出了挑战，并重新强调了细胞反应和损伤的后遗症的重要性，而不是损伤本身。新的工具和方法即将出现，在我们完全了解大分子损伤是否以及在多大程度上导致衰老表型之前，需要开发和实施这些工具和方法。
One of the most pervasive ideas regarding the causes of aging is that longevity is constrained in large measure by damage to macromolecules. An increasing body of cellular and molecular data, generated over the past decade or so, has generally supported this "damage accumulation" hypothesis of aging. There remain unanswered questions regarding which types of damage are most important for driving aging. In addition, there have been recent challenges to the damage accumulation hypothesis and a new emphasis on the importance of cellular responses and the sequelae to damage, rather damage per se. New tools and approaches are on the horizon and will need to be developed and implemented before we can fully understand whether and to what extent macromolecular damage drives aging phenotypes.