Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study
Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study
复制标题
DOI：
10.1038/sj.jea.7500408
复制
发表时间：
2005-07-01
期刊：
影响因子：
--
通讯作者：
Salomaa, V
中科院分区：
文献类型：
--
作者：
Liao, DP;Heiss, G;Salomaa, V
为了弄清空气污染对健康的影响，我们对10,208名社区动脉粥样硬化风险（ARIC）双种族队列研究的中年男性和女性进行了基于人群的样本研究，研究了标准污染物（粒径< 10 μ m的颗粒物[PM10]、O-3、CO、NO2和SO2）与止血和炎症标志物的短期关联。对于每个参与者，我们在随机分配的队列检查日期前1 -3天计算了以下污染物暴露：PM10、CO、NO2和SO2为24小时平均值，O-3为8小时平均值。止血/炎症因子包括纤维蛋白原、VIII-C因子、血管性血友病因子（vWF）、白蛋白和白细胞计数（WBC）。线性回归模型用于调整心血管疾病（CVD）危险因素、人口统计学和社会经济变量以及相关气象变量。PM10每增加一个标准差（12.8 μ g/m(3)），糖尿病患者vWF升高3.93%，有心血管疾病史者血清白蛋白降低0.006 g/dl，显著（P < 0.05）相关。CO每增加1 SD （0.60 P .p.m.）与血清白蛋白降低0.018 g/dl显著相关（P < 0.01）。发现PM10与因子VIII-C、O-3与纤维蛋白原和vWF、SO2与因子VIII-C、白细胞和血清白蛋白存在显著的曲线关联，表明阈值效应。这项基于人群的研究表明，所分析的与冠心病高风险相关的止血/炎症标志物与环境相关的环境污染物呈负相关，在污染物分布的上范围和有糖尿病和冠心病阳性病史的人群中，相关性最强。
To elucidate the health effects of air pollution, the short-term association of criteria pollutants (particles < 10 mu m in diameter [PM10], O-3, CO, NO2, and SO2) with hemostatic and inflammatory markers were examined using a population-based sample of 10,208 middle-age males and females of the biracial cohort of Atherosclerosis Risk in Communities (ARIC) study. For each participant, we calculated the following pollutant exposures 1 - 3 days prior to the randomly allocated cohort examination date: PM10, CO, NO2, and SO2 as 24-h averages, and O-3 as an 8-h average of the hourly measures. The hemostatic/inflammatory factors included fibrinogen, factor VIII-C, von Willebrand factor (vWF), albumin, and white blood cell count (WBC). Linear regression models were used to adjust for cardiovascular disease (CVD) risk factors, demographic and socioeconomic variables, and relevant meteorological variables. One standard deviation (SD) increment of PM10 (12.8 mu g/m(3)) was significantly (P < 0.05) associated with 3.93% higher of vWF among diabetics and 0.006 g/dl lower of serum albumin among persons with a history of CVD. One SD increment of CO(0.60 p.p.m.) was significantly (P < 0.01) associated with 0.018 g/dl lower of serum albumin. Significant curvilinear associations, indicative of threshold effects, for PM10 with factor VIII-C, O-3 with fibrinogen and vWF, and SO2 with factor VIII-C, WBC, and serum albumin were found. This population-based study suggest that the hemostasis/inmflammation markers analyzed, which are linked to higher risk of CHD, are associated adversely with environmentally relevant ambient pollutants, with the strongest associations in the upper range of the pollutant distributions, and in persons with a positive history of diabetes and CHD.