Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization.
Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization.
复制标题
通过分子内迪克曼环化构建螺吲哚骨架
DOI：
10.1007/s13659-017-0131-0
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发表时间：
2017-06
影响因子：
4.7
通讯作者：
Xia C
中科院分区：
文献类型：
--
作者：
Wu T;Pan Z;Xia C
本论文发展了一种高效、直接的方法来构建结构多样的螺吲哚骨架，这是天然产物中重要的基本模体。在温和条件下，通过羟吲哚的分子内Dieckmann环化反应，以高产率顺利地得到了3，3 ′-吡咯烷酮基螺羟吲哚和螺吲哚啉-2-酮δ-内酯。
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3′-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular Dieckmann cyclization of oxindoles in excellent yield under mild conditions.