Social support and quality of life over time among adults living with HIV in the HAART era
Social support and quality of life over time among adults living with HIV in the HAART era
复制标题
DOI：
10.1016/s0277-9536(03)00314-9
复制
发表时间：
2004-04-01
影响因子：
5.4
通讯作者：
Renwick, R
中科院分区：
文献类型：
--
作者：
Burgoyne, R;Renwick, R
对加拿大41例成年艾滋病患者(PHA)的社会支持稳定性以及社会支持与健康相关生活质量之间的关系进行纵向评估。医疗结果研究社会支持调查(SSS)的特定结构维度、简明36(SF-36)生活质量测量的身体和精神部分以及临床因素(即症状学、免疫学/病毒学变量)被分三波进行测量：初始连续登记(T1,1997)、2年(T2,1999)和4年(T3,2001)，并使用重复测量方差分析评估变化，辅之以SSS和SF-36评级的Friedman检验。具有临床显著SSS变化(即大于0.5的标准化效应大小)的PHA样本的比例也被计算。探讨了SSS评分的改善和恶化对SF-36评分的影响，反之亦然。使用控制临床因素的多元回归分析来评估SSS和SF-36评分之间的关联，以及SSS评分和SF-36评分的变化之间的关联。交叉滞后分析被用来检验SSS和SF-36评分之间的预测潜力。临床结果表明，免疫学的改善受到症状和/或治疗副作用的影响。随着时间的推移，SSS和SF-36的平均评级是中等稳定的，但大约40%的患者的SSS评级在临床上出现了显著的4年下降。出现了一种趋势，即较差的SF-36精神结果预示着较差的情感和信息支持。除此之外，SSS和SF-36评级之间的关系似乎是互惠的。与基线和T3相比，T2时SSS和SF-36评分之间的横断面关联更明显。SSS和SF-36评级的变化在连续两年期间有一定的相关性，但在长期内没有相关性。T1-T2 SSS的变化与SF-36心理成分的变化有关。T2、T3、SSS的变化与SF-36物理成分的变化有关。在这项研究中，交叉滞后分析几乎没有解释PHA的社会支持和生活质量之间的关联的因果关系方向。(C)2003爱思唯尔有限公司。保留所有权利。
Stability in perceived social support and associations between social support and health-related quality of life for a sample of 41 adult outpatients living with HIV/AIDS (PHA) in Canada were assessed longitudinally. Construct-specific dimensions of the Medical Outcomes Study Social Support Survey (SSS), the Physical and Mental components of the Short-Form-36 (SF-36) quality of life measure, as well as clinical factors (i.e., symptomatology, immunologic/virologic variables), were measured in three waves: initial consecutive registration (T1, 1997), 2-year (T2, 1999) and 4-year (T3, 2001) follow-up, and evaluated for changes using repeated-measures analysis of variance, supplemented by Friedman tests for SSS and SF-36 ratings. Proportions of the PHA sample with clinically significant SSS changes (i.e., greater than 0.5 standardized effect size) were also calculated. Effects of improvement versus deterioration in SSS ratings on SF-36 ratings, and vice versa, were explored. Associations between SSS and SF-36 ratings, as well as between changes in SSS ratings and SF-36 ratings, were assessed using multiple regression analyses controlling for clinical factors. Cross-lagged analyses were conducted to examine predictive potential between SSS and SF-36 ratings. Clinical outcomes suggested immunologic improvement tempered by symptoms and/or treatment side effects. SSS and SF-36 mean ratings were moderately stable over time, but clinically significant 4-year decrements in SSS ratings occurred for approximately 40% of patients. A trend occurred in which poorer SF-36 mental outcomes portended poorer emotional and informational support. Otherwise, relations between SSS and SF-36 ratings appeared to be reciprocal. Cross-sectional associations between SSS and SF-36 ratings were more pronounced at T2 compared to baseline and T3. Changes in SSS and SF-36 ratings were somewhat related over the consecutive 2-year periods but not over the long term. T1-T2 SSS changes were associated with changes in the SF-36 mental component. T2 T3 SSS changes were associated with changes in the SF-36 physical component. Cross-lagged analyses yielded little explanation concerning direction of causation in terms of associations between social support and quality of life for the PHA in this study. (C) 2003 Elsevier Ltd. All rights reserved.