Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women
Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women
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DOI：
10.1210/jc.2006-0960
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发表时间：
2007-02-01
影响因子：
5.8
通讯作者：
Mingrone, Geltrude
中科院分区：
文献类型：
--
作者：
Manco, Melania;Fernandez-Real, J. Manuel;Mingrone, Geltrude
背景：肥胖可能被视为一种低度炎症状态。目的：本研究的目的是评估大规模减肥后促炎性脂肪细胞因子和先天免疫系统、心血管风险和胰岛素敏感性的变化。设计：这是一项纵向研究。背景：该研究在罗马天主教大学进行。对象和方法：对 10 名正常血糖耐受的肥胖女性在胆胰转移之前和之后 36 个月进行了评估（BPD）。使用正常血糖-高胰岛素钳夹评估葡萄糖敏感性（M 值）。检测了甘露聚糖结合凝集素 (MBL)、杀菌/通透性增加蛋白 (BPI)、α-防御素、可溶性 CD14 受体 (sCD14)、C 反应蛋白、脂联素、瘦素、内脏脂肪素、IL-6 和 TNF-α。 结果：大量减重（超重的 53%）后，瘦素 (P
Context: Obesity may be regarded as a low-grade inflammatory state.Objective: The aim of this study was to evaluate changes in pro-inflammatory adipocytokines and the innate immune system, cardiovascular risk, and insulin sensitivity after massive weight loss.Design: This was a longitudinal study.Setting: The study was conducted at Catholic University, Rome.Subjects and Methods: There were 10 normoglucose-tolerant obese women evaluated before and 36 months after bilio-pancreatic diversion (BPD). Glucose sensitivity (M value) was estimated using the euglycemic-hyperinsulinemic clamp. Mannan-binding lectin (MBL), bactericidal/permeability increasing protein (BPI), alpha-defensins, soluble CD14 receptor (sCD14), C-reactive protein, adiponectin, leptin, visfatin, IL-6, and TNF-alpha were assayed.Results: After massive weight loss (53% of excess body weight), leptin (P