Comparison of different quantification methods of late gadolinium enhancement in patients with hypertrophic cardiomyopathy
Comparison of different quantification methods of late gadolinium enhancement in patients with hypertrophic cardiomyopathy
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DOI：
10.1016/j.ejrad.2009.05.035
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Ruzyllo, Witold
中科院分区：
文献类型：
--
作者：
Spiewak, Mateusz;Malek, Lukasz A.;Ruzyllo, Witold
目的：关于晚期钆增强（LGE）的定量技术尚未达成共识。方法：对33例肥厚型心肌病（HCM）患者行心脏磁共振检查，比较不同方法定量LGE的价值。首先，由经验丰富的阅片者对LGE进行视觉评估，并与不同的阈值技术进行比较：远端心肌平均信号强度（SI）以上1 SD ~ 6SD，增强区最大信号强度（SI）50%以上（FWHM），远端心肌峰值信号强度以上。LGE的中位质量因所用的定量方法而异，使用1 SD阈值时最高[75.5 g，四分位距（IQR）：63.3-112.3 g]，FWHM方法最低（8.4 g，IQR：4.3-13.3 g）。与目视评估相比，使用6SD阈值和FWHM评估的LGE质量无差异（分别为p=0.19和p=0.1）;与目视分析相比，所有其他阈值技术提供的中位LGE尺寸存在显著差异。除FWHM外，所有阈值的结果均与视觉评估显著相关，其中6SD的相关性最强（rho=0.956，p
Aim: There is no consensus regarding the technique of quantification of late gadolinium enhancement (LGE). The aim of the study was to compare different methods of LGE quantification in patients with hypertrophic cardiomyopathy (HCM).Methods: Cardiac magnetic resonance was performed in 33 patients with HCM. First, LGE was quantified by visual assessment by the team of experienced readers and compared with different thresholding techniques: from 1SD to 6SD above mean signal intensity (SI) of remote myocardium, above 50% of maximal SI of the enhanced area (full-width at half maximum, FWHM) and above peak SI of remote myocardium.Results LGE was present in 25 (78%) of patients. The median mass of LGE varied greatly depending on the quantification method used and was highest with the utilization of 1SD threshold [75.5 g, interquartile range (IQR): 63.3-112.3 g] and lowest for FWHM method (8.4 g, IQR: 4.3-13.3 g). There was no difference in mass of LGE as assessed with 6SD threshold and FWHM when compared to visual assessment (p=0.19 and p=0.1, respectively); all other thresholding techniques provided significant differences in the median LGE size when compared to visual analysis. Results for all thresholds, except FWHM were significantly correlated with visual assessment with the strongest correlation for 6SD (rho=0.956, p