Memory T cells and their exhaustive differentiation in allograft tolerance and rejection.
Memory T cells and their exhaustive differentiation in allograft tolerance and rejection.
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DOI：
10.1097/mot.0b013e32834ee443
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发表时间：
2012-02
影响因子：
2.2
通讯作者：
Li XC
中科院分区：
文献类型：
--
作者：
Valujskikh A;Li XC
Memory T cells have emerged as a major threat to transplant survival; they are well equipped and well positioned to respond to antigens in an accelerated fashion. They participate in transplant rejection and resist interventions that usually contain naïve T cells. Thus, means to prevent memory T cells from attacking allotransplants is an important issue in transplantation. Recent studies in other models suggest that effector T cells, which include both freshly activated T cells and memory T cells, can acquire “an exhausted phenotype” in that they progressively loss their effector activities. This response is highly regulated, antigen specific, and driven primarily by antigen persistence. This exhausted phenotype has not been carefully explored in transplant models, and its role in transplant survival remains largely unknown. Studies of T cell exhaustion reveal additional facets of the fundamental mechanisms of transplant survival. T cell exhaustion may be an alternative pathway of preventing memory development. Future studies are needed to further improve our understanding of T cell exhaustion in transplantation.
