SLEEP FRAGMENTATION, AND CHANGES IN LOCOMOTOR-ACTIVITY AND BODY-TEMPERATURE IN TRYPANOSOME-INFECTED RATS
SLEEP FRAGMENTATION, AND CHANGES IN LOCOMOTOR-ACTIVITY AND BODY-TEMPERATURE IN TRYPANOSOME-INFECTED RATS
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DOI：
10.1016/0361-9230(94)00265-3
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发表时间：
1995-01-01
影响因子：
3.8
通讯作者：
BENTIVOGLIO, M
中科院分区：
文献类型：
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作者：
GRASSIZUCCONI, G;HARRIS, JA;BENTIVOGLIO, M
对布氏锥虫感染大鼠3周后的静息活动周期、体温周期和自然睡眠结构进行了研究。这种寄生虫属于锥虫的一种，它会在人类中引起非洲昏睡病，这是一种涉及内源性生物节律改变的神经精神综合征。在感染的大鼠中，在12小时：12小时的光周期中，在黑暗中检测到相当大的运动不足。在一些感染的动物中，24小时内体温的显著振荡消失。在其他感染的动物中，体温周期表现出较低的幅度和相位提前。在光照期间，感染组大鼠的平均温度略高于对照组。根据白天的脑电记录，对自发睡眠结构的详细分析显示，在锥虫感染期间，觉醒的相对比例增加，同步睡眠的百分比值下降。在感染的动物中也观察到平均REM潜伏期的显著缩短和同步睡眠的碎片化模式，导致REM-非REM睡眠序列的相当大的变化。这些结果表明，大鼠锥虫病导致显著的睡眠碎裂，以及运动活动和体温节律的改变。因此，大鼠的锥虫感染为结构完整的大脑提供了睡眠失调的实验模型，并可能提供了非洲昏睡病记录的内源性节律变化的动物模型。
The rest-activity and body temperature 24 h cycles, as well as the structure of spontaneous sleep, were studied in rats 3 weeks after infection with monomorphic Trypanosoma brucei brucei. This parasite belongs to the species of trypanosomes that causes in humans African sleeping sickness, a neuropsychiatric syndrome that involves alterations of endogenous biological rhythms. In the infected rats, entrained to a 12 h:12 h photoperiod, a considerable hypokinesia was detected during the hours of darkness. A significant oscillation of the body temperature during 24 h was lost in some infected animals. In the other infected animals, the body temperature cycle displayed a lower amplitude and a phase advance. The mean temperature was slightly higher in the infected than in control rats during the period of light. A detailed analysis of the structure of spontaneous sleep, based on daytime electroencephalographic recordings, revealed during trypanosome infection an increased relative proportion of wake, and a decreased percent value of synchronized sleep. A marked reduction of the mean REM latency and a fragmented pattern of synchronized sleep, resulting in a considerable alteration of the REM-non-REM sleep sequences, were also observed in the infected animals. These findings indicate that trypanosomiasis in the rat results in a striking sleep fragmentation, as well as in changes of locomotor activity and body temperature rhythm. Thus, trypanosome infection in the rat provides an experimental model of sleep dysregulation in a structurally intact brain, and may provide an animal model of endogenous rhythm changes documented in African sleeping sickness.