Urinary desmosine excretion in acute exacerbations of COPD: a preliminary report
Urinary desmosine excretion in acute exacerbations of COPD: a preliminary report
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DOI：
10.1053/rmed.2001.1224
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发表时间：
2002-02-01
影响因子：
4.3
通讯作者：
Snider, GL
中科院分区：
文献类型：
--
作者：
Fiorenza, D;Viglio, S;Snider, GL
锁链素（DES）是一种弹性蛋白衍生的交联氨基酸，不被代谢：因此，其尿液水平反映了弹性蛋白的分解。我们假设，弹性蛋白降解应增加的结果，增加肺部炎症在急性加重期的COPD和恢复后应减少，为了检验这一假设，我们测量DES在三个尿样从9个COPD受试者在前5天的急性加重和恢复后2个月。我们还测量了1秒用力呼气量（FEV 1），以监测急性发作对呼吸功能的影响。急性加重期间的平均（SD）FEV 1为45（15）%预测值，2个月后为57.8（16）%预测值（P=0.00001）。急性加重第1天DES平均排泄量为25.3（9）μ g（-1）肌酐，第3天为23.5（9）μ g（-1）肌酐，第5天为24（9）μ g（-1）肌酐。出院后60天尿DES排泄量平均值为20.9（7）μ g（-1）肌酐（P=0.049），与三个急性期值的平均值相比。在急性发作期间锁链素排泄量增加的幅度很小，为3.2 μ g（-1）肌酐或恢复锁链素值的16%。我们的结论是，有一个小的，但在统计学上显着增加，肺弹性蛋白分解在体内急性加重期的COPD。(C)2001 Elsevier Science Ltd.
Desmosine (DES) is an elastin-derived, cross-link amino acid, which is not metabolized: hence, its urinary levels reflect elastin breakdown. We hypothesized that elastin degradation should increase as a result of increased lung inflammation during an acute exacerbation of COPD and should decrease after recovery, To test this hypothesis we measured DES in three urine samples from nine COPD subjects during the first 5 days of an acute exacerbation and at 2 months after recovery. We also measured forced expiratory volume in I sec (FEV1) to monitor the effects of the exacerbation on ventilatory function. The mean (SD) FEV1 was 45 (15)% predicted during the exacerbation and 57.8 (16)% predicted 2 months later (P=0.00001). The mean (SD) DES excretion was 25.3 (9) mug g(-1) creatinine at day 1;23.5 (9) at day 3 and 24 (9) at day 5 of the exacerbation. The mean ( D) urinary DES excretion 60 days after discharge was 20.9 (7) mug g(-1) creatinine (P=0.049) in comparison with the mean of the three acute-phase values. The size of the increase in desmosine excretion during exacerbation is small, 3.2 mug g(-1) creatinine or 16% of the recovery desmosine value. We conclude that there is a small but statistically significant increase in lung elastin breakdown in the body during an acute exacerbation of COPD. (C) 2001 Elsevier Science Ltd.