Understanding the validity of self-reported positive family history of lymphoma in extended families to facilitate genetic epidemiology and clinical practice
Understanding the validity of self-reported positive family history of lymphoma in extended families to facilitate genetic epidemiology and clinical practice
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DOI：
10.1080/10428190701302434
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Clarke, Christina A.
中科院分区：
文献类型：
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作者：
Glaser, Sally L.;Chang, Ellen T.;Clarke, Christina A.
家族性霍奇金淋巴瘤（HL）的自我报告信息的有效性，流行病学研究和临床实践的重要性，是不确定的。我们试图验证55个家族性淋巴瘤先前报告的48名受试者在人口为基础的病例对照研究的HL妇女。在40例（83%）重新联系的受试者报告的44例诊断（80%）中，我们获得了36例（82%）的医疗文件。29例（81%）被证实为淋巴瘤，一级亲属和具有较大核心家庭和其他家庭疾病的受试者的准确性更好。14份家族性HL报告经验证为淋巴瘤13例（93%）和HL 9例（64%）。15例家族性NHL报告中，10例（67%）被确认为淋巴瘤，10例（67%）被确认为NHL。因此，HL患者和对照报告的家族性HL极有可能是淋巴瘤，即使在大家族成员中也是如此，但不太可能是HL本身。有效性可能因受试者的家庭规模和病史而异。
The validity of self-reported information about familial Hodgkin lymphoma (HL), important for epidemiologic research and clinical practice, is undetermined. We attempted to validate 55 familial lymphomas previously reported by 48 subjects in a population- based case-control study of HL in women. Of 44 diagnoses (80%) reported by 40 (83%) recontacted subjects, we obtained medical documentation for 36 (82%). Twenty-nine (81%) were validated as lymphoma, with accuracy better for first-degree relatives and subjects with larger nuclear families and other family illness. Fourteen reports of familial HL were validated as lymphoma for 13 (93%) and as HL for nine (64%). Fifteen reports of familial NHL were validated as lymphoma for 10 (67%) and as NHL for 10 (67%). Thus, familial HL reported by HL patients and controls is highly likely to be lymphoma even in extended family members but less likely to be HL per se. Validity may vary with the subject's family size and medical history.