A new reference preparation of human chorionic gonadotrophin and its subunits.
A new reference preparation of human chorionic gonadotrophin and its subunits.
复制标题
人绒毛膜促性腺激素及其亚基的新参比制剂。
DOI：
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复制
发表时间：
1976
影响因子：
11.1
通讯作者：
G. Ross
中科院分区：
文献类型：
--
作者：
R. Canfield;G. Ross
报道WHO生物标准化专家委员会建立CR119人绒毛膜促性腺激素（HCG）、CR119 HCGalpha和CR119 hcbeta(3)作为HCG及其亚基免疫测定的参比制剂。CR119促间质细胞活性为13450 IU/mg，体内促甲状腺和促卵泡活性成正比。这些活性的亚基制剂的效力一致小于。与未解离的激素相关，并且在重组时可恢复总量的约75%。每种制剂具有化学、物理和抗原性，与报道的同等纯制剂一致。
The establishment of CR119 human chorionic gonadotropin (HCG), CR119 HCGalpha, and CR119 HCGbeta(3) as reference preparations for the immunoassay of HCG and its subunits by the WHO Expert Committee on Biological Standardization is reported. The interstitial cell stimulating activity of CR119 HCG is 13,450 IU/mg and has proportional in vivo stimulatory activities for thyroid stimulating and follicle stimulating activities. The potencies of these activities for subunit preparations are uniformly less than .02 in relation to the undissociated hormone, and are recoverable in amounts approximately 75% of the total upon recombination. Each preparation has chemical, physical, and antigenic properties which are consistent with those reported for equally pure preparations.