Age-related pattern of KI and WU polyomavirus infection
Age-related pattern of KI and WU polyomavirus infection
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DOI：
10.1016/j.jcv.2008.05.003
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发表时间：
2008-09-01
影响因子：
8.8
通讯作者：
Klapper, P. E.
中科院分区：
文献类型：
--
作者：
Kiasari, B. Abedi;Vallely, P. J.;Klapper, P. E.
背景资料：两种最近发现的多瘤病毒KI和WU在呼吸道疾病的病因中的作用尚未确定。目的：确定KI和WU病毒的流行情况研究设计：采用单重、多重或真实的时间PCR方法对371例呼吸道标本进行KIV和WUV的筛查;结果：371份标本中，KIV阳性10份（2.70%），WUV阳性4份（1.08%），KIV和WUV合并感染的总患病率为3.77%。KIV和WUV在年龄15岁（11例患者）的上呼吸道或下呼吸道感染和>45岁（3例患者）的上呼吸道感染患者中确定。共感染被发现在5（50%）和3（75%）的KIV和WUV阳性samples，force.Conclusions：这项研究支持以前的结论，KIV和WUV检测在呼吸道可能是巧合，并反映重新激活的潜伏或持续感染这些病毒。本研究中KIV和WUV感染的年龄分布反映了其他人类多瘤病毒BK和JC的发现。(C)2008 Elsevier B. V.保留所有权利。
Background: The role of two recently identified polyomaviruses, KI and WU, in the causation of respiratory disease has not been established.Objectives: To determine the prevalence of KI and WU viruses (KIV and WUV) in 371 respiratory samples and evaluate their contribution to respiratory disease.Study Design: Specimens were screened for KIV and WUV using single, multiplex or real time PCR; co-infection with other respiratory viruses was evaluated.Results: Of the 371 samples analysed, 10 (2.70%) were positive for KIV and 4 (1.08%) were positive for WUV yielding an overall case prevalence of KIV and WUV infection of 3.77%. KIV and WUV were identified in patients aged 15 years (11 patients) with upper or lower respiratory tract infection and >45 years (3 patients) with upper respiratory tract infection. Co-infections were found in 5 (50%) and 3 (75%) of the KIV and WUV positive samples, respectively.Conclusions: This study supports previous conclusions that KIV and WUV detection in the respiratory tract may be coincidental and reflect reactivation of latent or persistent infection with these viruses. The age distribution of KIV and WUV infection in this study mirrors that found for the other human polyomaviruses, BK and JC. (C) 2008 Elsevier B.V. All rights reserved.