STUDY OF MOVEMENT-DISORDERS AND BRAIN IRON BY MR
STUDY OF MOVEMENT-DISORDERS AND BRAIN IRON BY MR
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DOI：
10.2214/ajr.149.2.365
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发表时间：
1987-08-01
影响因子：
5
通讯作者：
FAHN, S
中科院分区：
文献类型：
--
作者：
RUTLEDGE, JN;HILAL, SK;FAHN, S
重T2加权高场磁共振图像提供了一个独特的机会，评价锥体外系运动系统。图像受到少量自然产生的顺磁性物质（主要是铁）的影响，这些顺磁性物质描绘了新纹状体（尾状核和壳核）、苍白球、红核、黑质和齿状核，主要是由于继发于T2* 效应的信号降低。运动障碍与这些结构中的信号增加或减少或两者相关，这取决于病理过程。在对113例各种运动障碍患者的初步评价中，通过锥体外系通路的简化方案和异常运动、帕金森综合征/震颤、肌张力障碍、舞蹈病、肌阵挛和偏侧震颤的分类系统，可以使成像异常具有良好的相关性。帕金森综合征的特征是皮质-脑桥-小脑-肾上腺-红核-丘脑-皮质-脊髓束或黑质纹状体束的异常。肌张力障碍的特征是新纹状体的异常，主要影响壳核。舞蹈病也以新纹状体异常为特征，但主要影响尾状核。偏侧震颤的特征是影响丘脑底核或相关通路的病变。
Heavily T2-weighted high-field MR images provide a unique opportunity for the evaluation of the extrapyramidal motor system. The images are affected by the presence of small amounts of naturally occurring paramagnetic substances.sbd.principally iron.sbd.that delineate the neostriatum (caudate and putamen), globus pallidus, red nucleus, substantia nigra, and dentate nucleus, primarily by a decrease in signal secondary to the T2* effect. Movement disorders are associated with either increased or decreased signal or both in these structures, depending on the pathologic process. In the initial evaluation of 113 patients with a variety of movement disorders, good correlation of imaging abnormalities can be made with a simplified scheme of the extrapyramidal pathways and a system of classification of abnormal movements, parkinsonism/tremor, dystonia, chorea, myoclonus, and hemiballismus. Parkinsonisms are characterized by abnormalities of the cortico-ponto-cerebello-dentato-rubro-thalamo-cortico-spinal tract or the nigrostriatal tract. Dystonias are characterized by abnormalities of the neostriatum predominantly affected the putamen. Choreas are also characterized by abnormalities of the neostriatum but predominantly affecting the caudate nucleus. Hemiballismus is characterized by lesions affecting the subthalamic nucleus or associated pathway.