Increased levels of renal damage biomarkers caused by excess exposure to trivalent chromium in workers in tanneries
Increased levels of renal damage biomarkers caused by excess exposure to trivalent chromium in workers in tanneries
复制标题
制革厂工人过量接触三价铬导致肾损伤生物标志物水平升高
DOI：
10.1016/j.envres.2020.109770
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发表时间：
2020
影响因子：
8.3
通讯作者：
Kato Masashi
中科院分区：
文献类型：
--
作者：
Tsuchiyama Tomoyuki;Tazaki Akira;Al Hossain MM Aeorangajeb;Yajima Ichiro;Ahsan Nazmul;Akhand Anwarul Azim;Hashimoto Kazunori;Ohgami Nobutaka;Kato Masashi
背景皮革材料的生产工艺是在发展中国家使用大量三价铬[Cr(III)]进行的。需要对全球高污染制革厂数百万工人的健康风险进行评估。方法调查孟加拉国制革厂建成区废水样品中总铬及其化学形态的水平。对100名制革男工进行了尿铬和尿肾损伤标志物[尿总蛋白和肾损伤分子-1(KIM-1)]的流行病学调查。结果13个制革厂废水中总铬含量较高，平均尿总蛋白和肾损伤分子-1(KIM-1)的标准差分别为91.908,762和703,450μg/L。废水中总铬的99.99%以上是铬(III)，这表明制革厂的工人暴露在高浓度的铬(III)中。制革厂工人尿样中的铬含量(平均值为2.89g±2.23gμg/g肌酐)比之前报道的普通人群尿液中的铬含量高出24倍。多因素分析显示尿肌酸水平与尿中肾损害生物标志物水平显著相关。Nagelkerke假R2值还表明，铬水平是影响工人肾脏损害生物标志物水平的最大因素。结论我们的新结果表明，过量暴露于铬(III)可能是人类肾脏损害的一个风险。
BackgroundThe process for leather material production is carried out in developing countries using a large amount of trivalent chromium [Cr(III)]. Assesment of health risks for millions of workers in tanneries worldwide that are highly polluted with Cr(III) is needed.MethodsLevels of total Cr and its chemical species in wastewater samples from tannery built-up areas of Bangladesh were investigated. Cr-mediated renal damage was assessed in 100 male tannery workers by epidemiological analysis consisting of questionnaires and measurements of levels of urinary Cr and urinary renal damage markers [urinary levels of total protein and kidney injury molecule-1 (KIM-1)].ResultsHigh levels of total Cr (mean ± standard deviation = 1,908,762 ± 703,450 μg/L) were detected in wastewater samples from 13 sites of tanneries. More than 99.99% of total Cr in the wastewater was Cr(III), indicating that workers in the tanneries were exposed to large concentrations of Cr(III). Cr levels (mean ± standard, 2.89 ± 4.23 μg/g creatinine) in urine samples from the workers in tanneries were >24-fold higher than the levels in a general population previously reported. Multivariate analysis showed significant correlations between urinary levels of Cr and urinary levels of renal damage biomarkers. Nagelkerke PseudoR2values also showed that Cr level is the strongest contributor to the levels of renal damage biomarkers in the workers.ConclusionOur results newly suggest that excess exposure to Cr(III) could be a risk for renal damage in humans.