Proliferation in Cell Population Models with Age Structure
Proliferation in Cell Population Models with Age Structure
复制标题
具有年龄结构的细胞群模型的增殖
DOI：
--
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Thomas Ouillon
中科院分区：
文献类型：
--
作者：
F. Billy;J. Clairambault;Olivier Fercoq;S. Gaubert;T. Lepoutre;Thomas Ouillon
我们从生理结构偏微分模型的角度来研究组织中的增殖，重点是细胞群体中细胞分裂周期中的年龄同步化及其在相变检查点的控制。我们展示了最近在增殖细胞群体的单细胞水平上执行的基于荧光的技术(Fucci)如何识别模型参数，以及如何将其应用于调查健康和癌细胞群体。我们展示了这种建模方法如何允许设计癌症时间治疗的原始优化方法，通过控制肿瘤和健康细胞群体中潜在的增殖动力学的差异算子的特征值。
We study proliferation in tissues from the point of view of physiologically structured partial differential models, focusing on age synchronisation in the cell division cycle in cell populations and its control at phase transition checkpoints. We show how a recent fluorescence‐based technique (FUCCI) performed at the single cell level in proliferating cell populations allows identifying model parameters and how it may be applied to investigate healthy and cancer cell populations. We show how this modelling approach allows designing original optimisation methods for cancer chronotherapeutics, by controlling eigenvalues of differential operators underlying proliferation dynamics, in tumour and in healthy cell populations.