T-CELL SUBSETS IN ACUTE PSYCHOTIC SCHIZOPHRENIC-PATIENTS
T-CELL SUBSETS IN ACUTE PSYCHOTIC SCHIZOPHRENIC-PATIENTS
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DOI：
10.1016/0006-3223(94)91163-0
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发表时间：
1994-01-01
影响因子：
10.6
通讯作者：
LAOR, N
中科院分区：
文献类型：
--
作者：
ACHIRON, A;NOY, S;LAOR, N
双色流式细胞仪分析外周血淋巴细胞的16个未加热的精神分裂症患者在急性精神病发作和16个健康对照组进行评估T细胞亚群的差异。在精神分裂症患者中，我们观察到CD 4（+）2 H4（+）（抑制-诱导）和CD 8（+）2 H4（+）（抑制-效应）T细胞亚群减少。辅助性和抑制性T细胞上的2 H4（+）细胞标记物的选择性丢失与急性精神病的严重程度无关。我们的研究结果可能表明在急性精神病发作期间精神分裂症患者的免疫失衡的机制。
Two-color flow cytometric analysis was performed on peripheral blood lymphocytes of 16 unheated schizophrenic patients during an acute psychotic attack and 16 healthy control subjects to evaluate differences in T-cell subpopulations. In schizophrenic patients, we observed decrease in CD4(+)2H4(+) (suppressor-inducer) and CD8(+)2H4(+) (suppressor-effector) T-cell subsets. The selective loss 2H4(+) cell marker both on helper and suppressor T cells was not correlated to the severity of acute psychosis. Our results may indicate a mechanism of an immune disequilibrium in schizophrenic patients during an acute psychotic attack.