Attrition and related trends in scientific rigor: a score card for ART adherence intervention research and recommendations for future directions.
Attrition and related trends in scientific rigor: a score card for ART adherence intervention research and recommendations for future directions.
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DOI：
10.1007/s11904-008-0026-0
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发表时间：
2008-11-01
影响因子：
4.6
通讯作者：
O'Grady, Megan A
中科院分区：
文献类型：
--
作者：
Amico, K Rivet;Harman, Jennifer J;O'Grady, Megan A
干预试验的科学严谨性经常用于确定有效干预措施的系统中。在这些系统中，以及在综合研究机构的工作中，百分比损耗通常被认为是对有效性的致命威胁。然而，差别减员与总减员的百分比是主要关注的问题。确定了纵向设计中与科学严谨性相关的关键方法学、设计和分析问题，并评价了与这些问题相关的抗逆转录病毒治疗依从性干预措施（k = 51）的现有文献。虽然结果表明，这一机构的文献已经取得了进展的严谨性，需要改进的透明度报告参与者流，保留策略，处理缺失的数据，并保留和丢失的队列的特点。总的平均衰减率为30%，研究组的差异估计为9%。差异性自然减员继续被低估，而且更常用的总体自然减员百分比指标（尽管可能不太合适）也不能很好地代表差异性自然减员。
Scientific rigor in intervention trials is frequently used in systems that identify effective interventions for dissemination. In these systems, and in work that synthesizes bodies of research, percent attrition is often considered a fatal threat to validity. However, differential attrition, versus percent total, is of primary concern. Key methodologic, design, and analytic issues pertaining to scientific rigor in longitudinal designs were identified, and the current literature on antiretroviral therapy adherence interventions (k = 51) was evaluated in relation to these. Although results suggest that this body of literature has progressed in rigor, improvements are needed in transparency of reporting participant flow, retention strategies, handling of missing data, and characterization of retained and lost cohorts. Attrition averaged 30% total, and differential by study arm was estimated at 9%. Differential attrition continues to be underreported and is not well represented by the more frequently used, though arguably less appropriate, metric of overall percent attrition.