Set-up errors in patients undergoing image guided radiation treatment. Relationship to body mass index and weight loss
Set-up errors in patients undergoing image guided radiation treatment. Relationship to body mass index and weight loss
复制标题
DOI：
10.1080/02841860802256517
复制
发表时间：
2008-01-01
期刊：
影响因子：
3.1
通讯作者：
Brink, Carsten
中科院分区：
文献类型：
--
作者：
Johansen, Jorgen;Bertelsen, Anders;Brink, Carsten
背景本研究的目的是量化IGRT期间患者体位的设置误差，并将设置误差与患者特定因素（如体重、身高、BMI和体重减轻）相关联。患者和方法。对34例连续治疗的头颈癌患者（HN）和20例肺癌患者进行了研究。使用由真空垫和热塑性外壳组成的定制固定装置对患者进行定位。使用Elekta Synergy加速器进行治疗。根据标准化行动限方案获得锥形束采集，并与治疗前CT图像进行比较。将三次初始锥形束扫描的平均3D偏差与第10次和第20次治疗时的偏差进行比较，并通过线性回归分析与身高、体重和BMI相关，在HN中与体重减轻相关，以相对体重随时间的变化表示。结果HN前三个阶段的平移和旋转随机设置误差的SD分别为0.9 mm（左右）、1.1 mm（前后）、0.7 mm（头尾）和0.7度（LR轴）、0.5度（AP轴）和0.7度（CC轴）。肺癌患者的等效数据为1.1 mm（LR）、1.1 mm（AP）、1.5 mm（CC）和0.5度（LR轴）、0.6度（AP轴）和0.4度（CC轴）。HN和肺部的中位BMI分别为25.8（17.6 - 39.7）和23.7（17.4 - 38.8）。HN的中位每周体重变化为-0.3%（-2.0至1.1%）。通过分别分析HN和肺癌，未观察到治疗期间设置误差与身高、体重、BMI或体重变化之间存在统计学显著相关性，无论是否使用了最初三次锥形束扫描的3D偏差或第10次或第20次治疗的扫描。结论这项IGRT研究不支持放疗期间的摆位误差与患者身高、体重、BMI或体重减轻相关的假设。
Background. The purpose of this study was to quantify the set-up errors of patient positioning during IGRT and to correlate set-up errors to patient-specific factors such as weight, height, BMI, and weight loss. Patients and methods. Thirty four consecutively treated head-and-neck cancer patients (HN) and 20 lung cancer patients were investigated. Patients were positioned using customized immobilization devices consisting of vacuum cushions and thermoplastic shells. Treatment was given on an Elekta Synergy accelerator. Cone-beam acquisitions were obtained according to a standardized Action Limit protocol and compared to pre-treatment CT images. The average 3D deviation from three initial cone beam scans was compared to deviations at the 10th and 20th treatment session and correlated by linear regression analysis to height, weight, and BMI, and in HN to weight loss as expressed by the relative weight change over time. Results. The SD of the translational and rotational random set-up errors during the first three sessions for HN were 0.9 mm (Left-Right), 1.1 mm (Anterior-Posterior), 0.7 mm (Cranio-Caudal) and 0.7 degrees (LR-axis), 0.5 degrees (AP-axis), and 0.7 degrees (CC-axis). The equivalent data for lung cancer patients were 1.1 mm (LR), 1.1 mm (AP), 1.5 mm (CC) and 0.5 degrees (LR-axis), 0.6 degrees (AP-axis), and 0.4 degrees (CC-axis). The median BMI for HN and lung was 25.8 (17.6-39.7) and 23.7 (17.4-38.8), respectively. The median weekly weight change for HN was -0.3% (-2.0 to 1.1%). With HN and lung cancer analyzed separately, no statistically significant correlation was observed between set-up errors and height, weight, BMI, or weight change during treatment, irrespectively whether the 3D deviations from the initial three cone beam scans or scans from the 10th or 20th treatment sessions were used. Conclusion. This IGRT study did not support the hypothesis that set-up errors during radiotherapy are correlated to patient height, weight, BMI, or weight loss.