Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection.
Drug-eluting Ti wires with titania nanotube arrays for bone fixation and reduced bone infection.
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DOI：
10.1186/1556-276x-6-571
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发表时间：
2011-10-31
影响因子：
--
通讯作者：
Losic D
中科院分区：
文献类型：
--
作者：
Gulati K;Aw MS;Losic D
目前使用称为克氏针的不锈钢丝进行骨折固定的骨固定技术经常引起感染和骨骼负荷降低，从而导致植入物失效。创建具有药物洗脱特性的新导线以局部递送药物是解决这些问题中的一些问题的有吸引力的方法。本研究介绍了使用钛[Ti]丝与二氧化钛纳米管[TNT]阵列形成的药物输送能力，以设计用于骨科应用的替代骨固定工具。采用电化学阳极氧化法在钛丝表面制备了具有纳米管阵列结构的二氧化钛涂层，并负载抗生素（庆大霉素）作为骨抗菌药物的模型。首次成功制备了直径约为170 nm、长度约为70 μm的金属丝状TNT结构。评价了TNT-Ti丝的药物释放特性，显示出两相释放，具有突释（37%）和在11天内具有零级动力学的缓慢释放。这些结果证实了我们的系统作为药物洗脱工具应用于骨科应用的能力。TNT结构的生物相容性，更接近天然骨的弹性模量以及可能包含所需的药物，蛋白质或生长因子，使该系统成为替代传统骨植入物以预防骨感染并用于骨癌，骨髓炎和其他骨科疾病的靶向治疗的有希望的替代品。
Current bone fixation technology which uses stainless steel wires known as Kirschner wires for fracture fixing often causes infection and reduced skeletal load resulting in implant failure. Creating new wires with drug-eluting properties to locally deliver drugs is an appealing approach to address some of these problems. This study presents the use of titanium [Ti] wires with titania nanotube [TNT] arrays formed with a drug delivery capability to design alternative bone fixation tools for orthopaedic applications. A titania layer with an array of nanotube structures was synthesised on the surface of a Ti wire by electrochemical anodisation and loaded with antibiotic (gentamicin) used as a model of bone anti-bacterial drug. Successful fabrication of TNT structures with pore diameters of approximately 170 nm and length of 70 μm is demonstrated for the first time in the form of wires. The drug release characteristics of TNT-Ti wires were evaluated, showing a two-phase release, with a burst release (37%) and a slow release with zero-order kinetics over 11 days. These results confirmed our system's ability to be applied as a drug-eluting tool for orthopaedic applications. The established biocompatibility of TNT structures, closer modulus of elasticity to natural bones and possible inclusion of desired drugs, proteins or growth factors make this system a promising alternative to replace conventional bone implants to prevent bone infection and to be used for targeted treatment of bone cancer, osteomyelitis and other orthopaedic diseases.