A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission.
A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission.
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线虫中的单个神经元通过并行传输模式协调多个运动输出。
DOI：
10.1016/j.cub.2023.08.088
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Flavell,StevenW
中科院分区：
文献类型：
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作者：
Huang,Yung-Chi;Luo,Jinyue;Huang,Wenjia;Baker,CaseyM;Gomes,MatthewA;Meng,Bohan;Byrne,AlexandraB;Flavell,StevenW
动物产生广泛的高度协调的运动输出，这使它们能够执行有目的的行为。产生行为的回路中的单个神经元具有非凡的灵活性，因为它们表现出多种轴突投射、递质系统和神经活动模式。神经元的这些多功能特性如何使自适应行为的产生成为可能仍然是未知的。在这里，我们表明，HSN神经元在不同的时间尺度上唤起多种运动程序，使产卵过程中的一系列行为变化。使用HSN活动扰动和活体钙成像，我们发现HSN急剧增加产卵和运动，同时也使动物在几分钟内偏向低速停留行为。HSN对产卵和高速运动的急性效应是由不同的HSN递质和不同的HSN轴突隔室介导的。对停留的持久影响部分由HSN释放5-羟色胺介导，5-羟色胺被NSM吸收并重新释放，NSM是另一种直接引起停留的多巴胺能神经元。我们的研究结果显示了单个神经元的多功能特性如何使其能够诱导一系列协调的行为，并揭示了神经元可以相互借用血清素来控制行为。
Animals generate a wide range of highly coordinated motor outputs, which allows them to execute purposeful behaviors. Individual neurons in the circuits that generate behaviors have a remarkable capacity for flexibility as they exhibit multiple axonal projections, transmitter systems, and modes of neural activity. How these multi-functional properties of neurons enable the generation of adaptive behaviors remains unknown. Here, we show that the HSN neuron inC. elegansevokes multiple motor programs over different timescales to enable a suite of behavioral changes during egg laying. Using HSN activity perturbations andin vivocalcium imaging, we show that HSN acutely increases egg laying and locomotion while also biasing the animals toward low-speed dwelling behavior over minutes. The acute effects of HSN on egg laying and high-speed locomotion are mediated by separate sets of HSN transmitters and different HSN axonal compartments. The long-lasting effects on dwelling are mediated in part by HSN release of serotonin, which is taken up and re-released by NSM, another serotonergic neuron class that directly evokes dwelling. Our results show how the multi-functional properties of a single neuron allow it to induce a coordinated suite of behaviors and also reveal that neurons can borrow serotonin from one another to control behavior.